Search Results

Overview

Uniprot IDQ01780
Protein NameExosome complex component 10
Gene NameEXOSC10
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
178 TFRLLHAKNIIRPQL
592 EVAAGVKKSGPLPSA
710 APVSQAAKFDPSTKI
733 LAQVQVQKDSKEAVK
835 FAGNSKSKVSSQFDP
844 SSQFDPNKQTPSGKK
857 KKCIAAKKIKQSVGN
859 CIAAKKIKQSVGNKS
873 SMSFPTGKSDRGFRY

Function

Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPHOSPH6 with the RNA exosome involved in the maturation of 5.8S rRNA. Plays a role in the recruitment of replication protein A complex (RPA) and RAD51 to DNA double-strand breaks caused by irradiation, contributing to DNA repair by homologous recombination (PubMed:25632158, PubMed:31086179). Regulates levels of damage-induced RNAs in order to prevent DNA-RNA hybrid formation at DNA double-strand breaks and limit DNA end resection after damage (PubMed:31086179). Plays a role in oocyte development, maturation and survival (By similarity). Required for normal testis development and mitotic division of spermatogonia (By similarity). Plays a role in proper embryo development (By similarity). Required for global protein translation (PubMed:26857222, PubMed:36912080). Required for cell proliferation (PubMed:36912080). Regulates metabolism of C9orf72-derived repeat RNA that can be translated into toxic dipeptide repeat proteins (PubMed:32830871)

Protein Sequence

10 MAPPSTREPR 20 VLSATSATKS 30 DGEMVLPGFP 40 DADSFVKFAL 50 GSVVAVTKAS 60 GGLPQFGDEY 70 DFYRSFPGFQ 80 AFCETQGDRL 90 LQCMSRVMQY 100 HGCRSNIKDR 110 SKVTELEDKF 120 DLLVDANDVI 130 LERVGILLDE 140 ASGVNKNQQP 150 VLPAGLQVPK 160 TVVSSWNRKA 170 AEYGKKAKSE 180 TFRLLHAKNI 190 IRPQLKFREK 200 IDNSNTPFLP 210 KIFIKPNAQK 220 PLPQALSKER 230 RERPQDRPED 240 LDVPPALADF 250 IHQQRTQQVE 260 QDMFAHPYQY 270 ELNHFTPADA 280 VLQKPQPQLY 290 RPIEETPCHF 300 ISSLDELVEL 310 NEKLLNCQEF 320 AVDLEHHSYR 330 SFLGLTCLMQ 340 ISTRTEDFII 350 DTLELRSDMY 360 ILNESLTDPA 370 IVKVFHGADS 380 DIEWLQKDFG 390 LYVVNMFDTH 400 QAARLLNLGR 410 HSLDHLLKLY 420 CNVDSNKQYQ 430 LADWRIRPLP 440 EEMLSYARDD 450 THYLLYIYDK 460 MRLEMWERGN 470 GQPVQLQVVW 480 QRSRDICLKK 490 FIKPIFTDES 500 YLELYRKQKK 510 HLNTQQLTAF 520 QLLFAWRDKT 530 ARREDESYGY 540 VLPNHMMLKI 550 AEELPKEPQG 560 IIACCNPVPP 570 LVRQQINEMH 580 LLIQQAREMP 590 LLKSEVAAGV 600 KKSGPLPSAE 610 RLENVLFGPH 620 DCSHAPPDGY 630 PIIPTSGSVP 640 VQKQASLFPD 650 EKEDNLLGTT 660 CLIATAVITL 670 FNEPSAEDSK 680 KGPLTVAQKK 690 AQNIMESFEN 700 PFRMFLPSLG 710 HRAPVSQAAK 720 FDPSTKIYEI 730 SNRWKLAQVQ 740 VQKDSKEAVK 750 KKAAEQTAAR 760 EQAKEACKAA 770 AEQAISVRQQ 780 VVLENAAKKR 790 ERATSDPRTT 800 EQKQEKKRLK 810 ISKKPKDPEP 820 PEKEFTPYDY 830 SQSDFKAFAG 840 NSKSKVSSQF 850 DPNKQTPSGK 860 KCIAAKKIKQ 870 SVGNKSMSFP 880 TGKSDRGFRY NWPQR

Gene Ontology

Classification GO ID Description
Biological Process GO:0071028 nuclear mRNA surveillance
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0000791 euchromatin
Cellular Component GO:0000178 exosome (RNase complex)
Cellular Component GO:0016020 membrane
Cellular Component GO:0000176 nuclear exosome (RNase complex)
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032040 small-subunit processome
Molecular Function GO:0000175 3'-5'-RNA exonuclease activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0000166 nucleotide binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0004532 RNA exonuclease activity
Molecular Function GO:0003727 single-stranded RNA binding
Molecular Function GO:0070034 telomerase RNA binding
Biological Process GO:0071034 CUT catabolic process
Biological Process GO:0006281 DNA repair
Biological Process GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process GO:0071044 histone mRNA catabolic process
Biological Process GO:0000460 maturation of 5.8S rRNA
Biological Process GO:0032211 negative regulation of telomere maintenance via telomerase
Biological Process GO:0071040 nuclear polyadenylation-dependent antisense transcript catabolic process
Biological Process GO:0071039 nuclear polyadenylation-dependent CUT catabolic process
Biological Process GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process
Biological Process GO:0071036 nuclear polyadenylation-dependent snoRNA catabolic process
Biological Process GO:0071037 nuclear polyadenylation-dependent snRNA catabolic process
Biological Process GO:0000956 nuclear-transcribed mRNA catabolic process
Biological Process GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Biological Process GO:0071051 poly(A)-dependent snoRNA 3'-end processing
Biological Process GO:1904872 regulation of telomerase RNA localization to Cajal body
Biological Process GO:0042274 ribosomal small subunit biogenesis
Biological Process GO:0006401 RNA catabolic process
Biological Process GO:0006396 RNA processing
Biological Process GO:0006364 rRNA processing
Biological Process GO:0071038 TRAMP-dependent tRNA surveillance pathway

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.