Overview
| Uniprot ID | Q01826 |
|---|
| Protein Name | DNA-binding protein SATB1 |
|---|
| Gene Name | SATB1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 29 |
DPKGPPAKIARLEQN |
| 51 |
RLGSTGAKMQGVPLK |
Function
Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain as HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (By similarity)
Protein Sequence
10
MDHLNEATQG
20
KEHSEMSNNV
30
SDPKGPPAKI
40
ARLEQNGSPL
50
GRGRLGSTGA
60
KMQGVPLKHS
70
GHLMKTNLRK
80
GTMLPVFCVV
90
EHYENAIEYD
100
CKEEHAEFVL
110
VRKDMLFNQL
120
IEMALLSLGY
130
SHSSAAQAKG
140
LIQVGKWNPV
150
PLSYVTDAPD
160
ATVADMLQDV
170
YHVVTLKIQL
180
HSCPKLEDLP
190
PEQWSHTTVR
200
NALKDLLKDM
210
NQSSLAKECP
220
LSQSMISSIV
230
NSTYYANVSA
240
AKCQEFGRWY
250
KHFKKTKDMM
260
VEMDSLSELS
270
QQGANHVNFG
280
QQPVPGNTAE
290
QPPSPAQLSH
300
GSQPSVRTPL
310
PNLHPGLVST
320
PISPQLVNQQ
330
LVMAQLLNQQ
340
YAVNRLLAQQ
350
SLNQQYLNHP
360
PPVSRSMNKP
370
LEQQVSTNTE
380
VSSEIYQWVR
390
DELKRAGISQ
400
AVFARVAFNR
410
TQGLLSEILR
420
KEEDPKTASQ
430
SLLVNLRAMQ
440
NFLQLPEAER
450
DRIYQDERER
460
SLNAASAMGP
470
APLISTPPSR
480
PPQVKTATIA
490
TERNGKPENN
500
TMNINASIYD
510
EIQQEMKRAK
520
VSQALFAKVA
530
ATKSQGWLCE
540
LLRWKEDPSP
550
ENRTLWENLS
560
MIRRFLSLPQ
570
PERDAIYEQE
580
SNAVHHHGDR
590
PPHIIHVPAE
600
QIQQQQQQQQ
610
QQQQQQQAPP
620
PPQPQQQPQT
630
GPRLPPRQPT
640
VASPAESDEE
650
NRQKTRPRTK
660
ISVEALGILQ
670
SFIQDVGLYP
680
DEEAIQTLSA
690
QLDLPKYTII
700
KFFQNQRYYL
710
KHHGKLKDNS
720
GLEVDVAEYK
730
EEELLKDLEE
740
SVQDKNTNTL
750
FSVKLEEELS
760
VEGNTDINTD
LKD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0016604 |
nuclear body |
| Cellular Component |
GO:0016363 |
nuclear matrix |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0016605 |
PML body |
| Molecular Function |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function |
GO:0001227 |
DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function |
GO:0003690 |
double-stranded DNA binding |
| Molecular Function |
GO:0000978 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function |
GO:0000977 |
RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| Molecular Function |
GO:0043565 |
sequence-specific DNA binding |
| Biological Process |
GO:0006325 |
chromatin organization |
| Biological Process |
GO:0006338 |
chromatin remodeling |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
Reference
PMID: N/A