Search Results
Overview
| Uniprot ID | Q01844 |
|---|---|
| Protein Name | RNA-binding protein EWS |
| Gene Name | EWSR1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 641 | GGRGGPGKMDKGEHR |
| 644 | GGPGKMDKGEHRQER |
Function
Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Might normally function as a transcriptional repressor (PubMed:10767297). EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes
Protein Sequence
10
MASTDYSTYS
20
QAAAQQGYSA
30
YTAQPTQGYA
40
QTTQAYGQQS
50
YGTYGQPTDV
60
SYTQAQTTAT
70
YGQTAYATSY
80
GQPPTGYTTP
90
TAPQAYSQPV
100
QGYGTGAYDT
110
TTATVTTTQA
120
SYAAQSAYGT
130
QPAYPAYGQQ
140
PAATAPTRPQ
150
DGNKPTETSQ
160
PQSSTGGYNQ
170
PSLGYGQSNY
180
SYPQVPGSYP
190
MQPVTAPPSY
200
PPTSYSSTQP
210
TSYDQSSYSQ
220
QNTYGQPSSY
230
GQQSSYGQQS
240
SYGQQPPTSY
250
PPQTGSYSQA
260
PSQYSQQSSS
270
YGQQSSFRQD
280
HPSSMGVYGQ
290
ESGGFSGPGE
300
NRSMSGPDNR
310
GRGRGGFDRG
320
GMSRGGRGGG
330
RGGMGSAGER
340
GGFNKPGGPM
350
DEGPDLDLGP
360
PVDPDEDSDN
370
SAIYVQGLND
380
SVTLDDLADF
390
FKQCGVVKMN
400
KRTGQPMIHI
410
YLDKETGKPK
420
GDATVSYEDP
430
PTAKAAVEWF
440
DGKDFQGSKL
450
KVSLARKKPP
460
MNSMRGGLPP
470
REGRGMPPPL
480
RGGPGGPGGP
490
GGPMGRMGGR
500
GGDRGGFPPR
510
GPRGSRGNPS
520
GGGNVQHRAG
530
DWQCPNPGCG
540
NQNFAWRTEC
550
NQCKAPKPEG
560
FLPPPFPPPG
570
GDRGRGGPGG
580
MRGGRGGLMD
590
RGGPGGMFRG
600
GRGGDRGGFR
610
GGRGMDRGGF
620
GGGRRGGPGG
630
PPGPLMEQMG
640
GRRGGRGGPG
650
KMDKGEHRQE
RRDRPY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0003712 | transcription coregulator activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
Reference
PMID: N/A