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Overview

Uniprot IDQ01954
Protein NameZinc finger protein basonuclin-1
Gene NameBNC1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
730 DICKKTFKNACSVKI

Function

Transcriptional activator (By similarity). It is likely involved in the regulation of keratinocytes terminal differentiation in squamous epithelia and hair follicles (PubMed:8034748). Required for the maintenance of spermatogenesis (By similarity). It is involved in the positive regulation of oocyte maturation, probably acting through the control of BMP15 levels and regulation of AKT signaling cascade (PubMed:30010909). May also play a role in the early development of embryos (By similarity)

Protein Sequence

10 MRRRPPSRGG 20 RGAARARETR 30 RQPRHRSGRR 40 MAEAISCTLN 50 CSCQSFKPGK 60 INHRQCDQCK 70 HGWVAHALSK 80 LRIPPMYPTS 90 QVEIVQSNVV 100 FDISSLMLYG 110 TQAIPVRLKI 120 LLDRLFSVLK 130 QDEVLQILHA 140 LDWTLQDYIR 150 GYVLQDASGK 160 VLDHWSIMTS 170 EEEVATLQQF 180 LRFGETKSIV 190 ELMAIQEKEE 200 QSIIIPPSTA 210 NVDIRAFIES 220 CSHRSSSLPT 230 PVDKGNPSSI 240 HPFENLISNM 250 TFMLPFQFFN 260 PLPPALIGSL 270 PEQYMLEQGH 280 DQSQDPKQEV 290 HGPFPDSSFL 300 TSSSTPFQVE 310 KDQCLNCPDA 320 ITKKEDSTHL 330 SDSSSYNIVT 340 KFERTQLSPE 350 AKVKPERNSL 360 GTKKGRVFCT 370 ACEKTFYDKG 380 TLKIHYNAVH 390 LKIKHKCTIE 400 GCNMVFSSLR 410 SRNRHSANPN 420 PRLHMPMNRN 430 NRDKDLRNSL 440 NLASSENYKC 450 PGFTVTSPDC 460 RPPPSYPGSG 470 EDSKGQPAFP 480 NIGQNGVLFP 490 NLKTVQPVLP 500 FYRSPATPAE 510 VANTPGILPS 520 LPLLSSSIPE 530 QLISNEMPFD 540 ALPKKKSRKS 550 SMPIKIEKEA 560 VEIANEKRHN 570 LSSDEDMPLQ 580 VVSEDEQEAC 590 SPQSHRVSEE 600 QHVQSGGLGK 610 PFPEGERPCH 620 RESVIESSGA 630 ISQTPEQATH 640 NSERETEQTP 650 ALIMVPREVE 660 DGGHEHYFTP 670 GMEPQVPFSD 680 YMELQQRLLA 690 GGLFSALSNR 700 GMAFPCLEDS 710 KELEHVGQHA 720 LARQIEENRF 730 QCDICKKTFK 740 NACSVKIHHK 750 NMHVKEMHTC 760 TVEGCNATFP 770 SRRSRDRHSS 780 NLNLHQKALS 790 QEALESSEDH 800 FRAAYLLKDV 810 AKEAYQDVAF 820 TQQASQTSVI 830 FKGTSRMGSL 840 VYPITQVHSA 850 SLESYNSGPL 860 SEGTILDLST 870 TSSMKSESSS 880 HSSWDSDGVS 890 EEGTVLMEDS 900 DGNCEGSSLV 910 PGEDEYPICV 920 LMEKADQSLA 930 SLPSGLPITC 940 HLCQKTYSNK 950 GTFRAHYKTV 960 HLRQLHKCKV 970 PGCNTMFSSV 980 RSRNRHSQNP 990 NLHKSLASSP SHLQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0001216 DNA-binding transcription activator activity
Molecular Function GO:0000182 rDNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0030154 cell differentiation
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0008544 epidermis development
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:1900195 positive regulation of oocyte maturation
Biological Process GO:0045943 positive regulation of transcription by RNA polymerase I
Biological Process GO:0006356 regulation of transcription by RNA polymerase I
Biological Process GO:0007283 spermatogenesis

Reference

PMID: N/A