Overview
| Uniprot ID | Q01968 |
|---|
| Protein Name | Inositol polyphosphate 5-phosphatase OCRL |
|---|
| Gene Name | OCRL |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 208 |
KVTNTMRKLFVPNTQ |
Function
Catalyzes the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2 (PubMed:10764818, PubMed:15474001, PubMed:7761412, PubMed:9430698). Also, is able to hydrolyze the 5-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate (PubMed:15474001, PubMed:40969890, PubMed:7761412). Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes (PubMed:21971085). Involved in primary cilia assembly (PubMed:22228094, PubMed:22543976). Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling (PubMed:22072788)
Protein Sequence
10
MEPPLPVGAQ
20
PLATVEGMEM
30
KGPLREPCAL
40
TLAQRNGQYE
50
LIIQLHEKEQ
60
HVQDIIPINS
70
HFRCVQEAEE
80
TLLIDIASNS
90
GCKIRVQGDW
100
IRERRFEIPD
110
EEHCLKFLSA
120
VLAAQKAQSQ
130
LLVPEQKDSS
140
SWYQKLDTKD
150
KPSVFSGLLG
160
FEDNFSSMNL
170
DKKINSQNQP
180
TGIHREPPPP
190
PFSVNKMLPR
200
EKEASNKEQP
210
KVTNTMRKLF
220
VPNTQSGQRE
230
GLIKHILAKR
240
EKEYVNIQTF
250
RFFVGTWNVN
260
GQSPDSGLEP
270
WLNCDPNPPD
280
IYCIGFQELD
290
LSTEAFFYFE
300
SVKEQEWSMA
310
VERGLHSKAK
320
YKKVQLVRLV
330
GMMLLIFARK
340
DQCRYIRDIA
350
TETVGTGIMG
360
KMGNKGGVAV
370
RFVFHNTTFC
380
IVNSHLAAHV
390
EDFERRNQDY
400
KDICARMSFV
410
VPNQTLPQLN
420
IMKHEVVIWL
430
GDLNYRLCMP
440
DANEVKSLIN
450
KKDLQRLLKF
460
DQLNIQRTQK
470
KAFVDFNEGE
480
IKFIPTYKYD
490
SKTDRWDSSG
500
KCRVPAWCDR
510
ILWRGTNVNQ
520
LNYRSHMELK
530
TSDHKPVSAL
540
FHIGVKVVDE
550
RRYRKVFEDS
560
VRIMDRMEND
570
FLPSLELSRR
580
EFVFENVKFR
590
QLQKEKFQIS
600
NNGQVPCHFS
610
FIPKLNDSQY
620
CKPWLRAEPF
630
EGYLEPNETV
640
DISLDVYVSK
650
DSVTILNSGE
660
DKIEDILVLH
670
LDRGKDYFLT
680
ISGNYLPSCF
690
GTSLEALCRM
700
KRPIREVPVT
710
KLIDLEEDSF
720
LEKEKSLLQM
730
VPLDEGASER
740
PLQVPKEIWL
750
LVDHLFKYAC
760
HQEDLFQTPG
770
MQEELQQIID
780
CLDTSIPETI
790
PGSNHSVAEA
800
LLIFLEALPE
810
PVICYELYQR
820
CLDSAYDPRI
830
CRQVISQLPR
840
CHRNVFRYLM
850
AFLRELLKFS
860
EYNSVNANMI
870
ATLFTSLLLR
880
PPPNLMARQT
890
PSDRQRAIQF
900
LLGFLLGSEE
D
Gene Ontology
| Classification |
GO ID |
Description |
| Molecular Function |
GO:0043813 |
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity |
| Cellular Component |
GO:0005929 |
cilium |
| Cellular Component |
GO:0005905 |
clathrin-coated pit |
| Cellular Component |
GO:0030136 |
clathrin-coated vesicle |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005769 |
early endosome |
| Cellular Component |
GO:0031901 |
early endosome membrane |
| Cellular Component |
GO:0005795 |
Golgi stack |
| Cellular Component |
GO:0005798 |
Golgi-associated vesicle |
| Cellular Component |
GO:0005764 |
lysosome |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0043005 |
neuron projection |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0030670 |
phagocytic vesicle membrane |
| Cellular Component |
GO:0001750 |
photoreceptor outer segment |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0005802 |
trans-Golgi network |
| Molecular Function |
GO:0005096 |
GTPase activator activity |
| Molecular Function |
GO:0052745 |
inositol phosphate phosphatase activity |
| Molecular Function |
GO:0052659 |
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity |
| Molecular Function |
GO:0052658 |
inositol-1,4,5-trisphosphate 5-phosphatase activity |
| Molecular Function |
GO:0034596 |
phosphatidylinositol phosphate 4-phosphatase activity |
| Molecular Function |
GO:0034485 |
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity |
| Molecular Function |
GO:0004439 |
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity |
| Molecular Function |
GO:0031267 |
small GTPase binding |
| Biological Process |
GO:0060271 |
cilium assembly |
| Biological Process |
GO:0043647 |
inositol phosphate metabolic process |
| Biological Process |
GO:0006629 |
lipid metabolic process |
| Biological Process |
GO:0061024 |
membrane organization |
| Biological Process |
GO:0006661 |
phosphatidylinositol biosynthetic process |
| Biological Process |
GO:0046856 |
phosphatidylinositol dephosphorylation |
| Biological Process |
GO:0007165 |
signal transduction |
Reference
[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.