Search Results

Overview

Uniprot IDQ01995
Protein NameTransgelin
Gene NameTAGLN
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
121 TVDLFEGKDMAAVQR
140 LGSLAVTKNDGHYRG
17 MSREVQSKIEKKYDE
172 ESQLQEGKHVIGLQM
21 VQSKIEKKYDEELEE
4 ****MANKGPSYGMS
75 SLYPDGSKPVKVPEN

Function

Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence

Protein Sequence

10 MANKGPSYGM 20 SREVQSKIEK 30 KYDEELEERL 40 VEWIIVQCGP 50 DVGRPDRGRL 60 GFQVWLKNGV 70 ILSKLVNSLY 80 PDGSKPVKVP 90 ENPPSMVFKQ 100 MEQVAQFLKA 110 AEDYGVIKTD 120 MFQTVDLFEG 130 KDMAAVQRTL 140 MALGSLAVTK 150 NDGHYRGDPN 160 WFMKKAQEHK 170 REFTESQLQE 180 GKHVIGLQMG 190 SNRGASQAGM 200 TGYGRPRQII S

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Molecular Function GO:0003779 actin binding
Biological Process GO:0030855 epithelial cell differentiation
Biological Process GO:0007517 muscle organ development

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[5] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[6] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[7] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.