Search Results

Overview

Uniprot ID	Q02038
Protein Name	Neurolysin, mitochondrial
Gene Name	NLN
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
254	HYFPVMKKCCIPETR
341	REFILNLKKKECEEK

Function

Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1

Protein Sequence

10 MIVRCLSAAR 20 RLHRVGGSGI 30 LLRMTLGREA 40 MSPLQAMSSY 50 TVDGRNVLRW 60 DLSPEQIKRR 70 TEELIAQTKQ 80 VYDDIGMLDI 90 EEVTYENCLQ 100 ALADVEVKYI 110 VERTMLDFPQ 120 HVSSDKEVRA 130 ASTEADKRLS 140 RFDIEMSMRE 150 DIFLRIVRLK 160 ETCDLGKIKP 170 EARRYLEKSV 180 KMGKRNGLHL 190 PEQVQNEIKA 200 MKKRMSELCI 210 DFNKNLNEDD 220 TFLVFSKAEL 230 GALPDDFIDS 240 LEKTDDNKYK 250 ITLKYPHYFP 260 VMKKCCIPET 270 RRKMEMAFNT 280 RCKEENTIIL 290 QELLPLRAKV 300 AKLLGYSTHA 310 DFVLEMNTAK 320 STHHVTAFLD 330 DLSQKLKPLG 340 EAEREFILNL 350 KKKECEEKGF 360 EYDGKINAWD 370 LHYYMTQTEE 380 LKYSVDQEIL 390 KEYFPIEVVT 400 EGLLNIYQEL 410 LGLSFEQVTD 420 AHVWNKSVTL 430 YTVKDKATGE 440 VLGQFYLDLY 450 PREGKYNHAA 460 CFGLQPGCLL 470 PDGSRMMSVA 480 ALVVNFSQPR 490 AGRPSLLRHD 500 EVRTYFHEFG 510 HVMHQICAQT 520 DFARFSGTNV 530 ETDFVEVPSQ 540 MLENWVWDTD 550 SLRRLSKHYK 560 DGSPITDDLL 570 EKLVASRLVN 580 TGLLTLRQIV 590 LSKVDQSLHT 600 NTSLDAASEY 610 AKYCTEILGV 620 AATPGTNMPA 630 TFGHLAGGYD 640 GQYYGYLWSE 650 VFSMDMFYSC 660 FKKEGIMNPE 670 VGMKYRNLIL 680 KPGGSLDGMD 690 MLQNFLKREP 700 NQKAFLMSRG LHAP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005758	mitochondrial intermembrane space
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0004175	endopeptidase activity
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0004222	metalloendopeptidase activity
Biological Process	GO:0006508	proteolysis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.