Search Results
Overview
| Uniprot ID | Q02127 |
|---|---|
| Protein Name | Dihydroorotate dehydrogenase (quinone), mitochondrial |
| Gene Name | DHODH |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 226 | GLRSLQGKAELRRLL |
Function
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway
Protein Sequence
10
MAWRHLKKRA
20
QDAVIILGGG
30
GLLFASYLMA
40
TGDERFYAEH
50
LMPTLQGLLD
60
PESAHRLAVR
70
FTSLGLLPRA
80
RFQDSDMLEV
90
RVLGHKFRNP
100
VGIAAGFDKH
110
GEAVDGLYKM
120
GFGFVEIGSV
130
TPKPQEGNPR
140
PRVFRLPEDQ
150
AVINRYGFNS
160
HGLSVVEHRL
170
RARQQKQAKL
180
TEDGLPLGVN
190
LGKNKTSVDA
200
AEDYAEGVRV
210
LGPLADYLVV
220
NVSSPNTAGL
230
RSLQGKAELR
240
RLLTKVLQER
250
DGLRRVHRPA
260
VLVKIAPDLT
270
SQDKEDIASV
280
VKELGIDGLI
290
VTNTTVSRPA
300
GLQGALRSET
310
GGLSGKPLRD
320
LSTQTIREMY
330
ALTQGRVPII
340
GVGGVSSGQD
350
ALEKIRAGAS
360
LVQLYTALTF
370
WGPPVVGKVK
380
RELEALLKEQ
390
GFGGVTDAIG
ADHRR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004151 | dihydroorotase activity |
| Molecular Function | GO:0106430 | dihydroorotate dehydrogenase (quinone) activity |
| Molecular Function | GO:0004152 | dihydroorotate dehydrogenase activity |
| Biological Process | GO:0006207 | 'de novo' pyrimidine nucleobase biosynthetic process |
| Biological Process | GO:0044205 | 'de novo' UMP biosynthetic process |
| Biological Process | GO:0009220 | pyrimidine ribonucleotide biosynthetic process |
| Biological Process | GO:0006225 | UDP biosynthetic process |
Reference
PMID: N/A