Search Results

Overview

Uniprot IDQ02241
Protein NameKinesin-like protein KIF23
Gene NameKIF23
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
16 PRKPTVKKGSQTNLK
183 REAMPNPKTSSSKRQ
599 ELETQNQKLQRQFSD
636 CERRVAAKQLEMQNK
655 DEKLKQLKAIVTEPK
741 PTYNTPLKVTSIARR
877 EIETKLIKGDIYKTR
956 YQHHAQPKRKKP***

Function

Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro

Protein Sequence

10 MKSARAKTPR 20 KPTVKKGSQT 30 NLKDPVGVYC 40 RVRPLGFPDQ 50 ECCIEVINNT 60 TVQLHTPEGY 70 RLNRNGDYKE 80 TQYSFKQVFG 90 THTTQKELFD 100 VVANPLVNDL 110 IHGKNGLLFT 120 YGVTGSGKTH 130 TMTGSPGEGG 140 LLPRCLDMIF 150 NSIGSFQAKR 160 YVFKSNDRNS 170 MDIQCEVDAL 180 LERQKREAMP 190 NPKTSSSKRQ 200 VDPEFADMIT 210 VQEFCKAEEV 220 DEDSVYGVFV 230 SYIEIYNNYI 240 YDLLEEVPFD 250 PIKPKPPQSK 260 LLREDKNHNM 270 YVAGCTEVEV 280 KSTEEAFEVF 290 WRGQKKRRIA 300 NTHLNRESSR 310 SHSVFNIKLV 320 QAPLDADGDN 330 VLQEKEQITI 340 SQLSLVDLAG 350 SERTNRTRAE 360 GNRLREAGNI 370 NQSLMTLRTC 380 MDVLRENQMY 390 GTNKMVPYRD 400 SKLTHLFKNY 410 FDGEGKVRMI 420 VCVNPKAEDY 430 EENLQVMRFA 440 EVTQEVEVAR 450 PVDKAICGLT 460 PGRRYRNQPR 470 GPVGNEPLVT 480 DVVLQSFPPL 490 PSCEILDIND 500 EQTLPRLIEA 510 LEKRHNLRQM 520 MIDEFNKQSN 530 AFKALLQEFD 540 NAVLSKENHM 550 QGKLNEKEKM 560 ISGQKLEIER 570 LEKKNKTLEY 580 KIEILEKTTT 590 IYEEDKRNLQ 600 QELETQNQKL 610 QRQFSDKRRL 620 EARLQGMVTE 630 TTMKWEKECE 640 RRVAAKQLEM 650 QNKLWVKDEK 660 LKQLKAIVTE 670 PKTEKPERPS 680 RERDREKVTQ 690 RSVSPSPVPL 700 SSNYIAQISN 710 GQQLMSQPQL 720 HRRSNSCSSI 730 SVASCISEWE 740 QKIPTYNTPL 750 KVTSIARRRQ 760 QEPGQSKTCI 770 VSDRRRGMYW 780 TEGREVVPTF 790 RNEIEIEEDH 800 CGRLLFQPDQ 810 NAPPIRLRHR 820 RSRSAGDRWV 830 DHKPASNMQT 840 ETVMQPHVPH 850 AITVSVANEK 860 ALAKCEKYML 870 THQELASDGE 880 IETKLIKGDI 890 YKTRGGGQSV 900 QFTDIETLKQ 910 ESPNGSRKRR 920 SSTVAPAQPD 930 GAESEWTDVE 940 TRCSVAVEMR 950 AGSQLGPGYQ 960 HHAQPKRKKP

Gene Ontology

Classification GO ID Description
Biological Process GO:0032467 positive regulation of cytokinesis
Cellular Component GO:0097149 centralspindlin complex
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0090543 Flemming body
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005871 kinesin complex
Cellular Component GO:0005874 microtubule
Cellular Component GO:0030496 midbody
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0072686 mitotic spindle
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005819 spindle
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0003777 microtubule motor activity
Biological Process GO:0007018 microtubule-based movement
Biological Process GO:0000281 mitotic cytokinesis
Biological Process GO:0000022 mitotic spindle elongation
Biological Process GO:0051256 mitotic spindle midzone assembly

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.