Search Results

Overview

Uniprot ID	Q02252
Protein Name	Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial
Gene Name	ALDH6A1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
113	LRYQQLIKENLKEIA
117	QLIKENLKEIAKLIT
121	ENLKEIAKLITLEQG
264	ISFVGSNKAGEYIFE
287	VQANMGAKNHGVVMP
331	VLVGEAKKWLPELVE
341	PELVEHAKNLRVNAG
364	PLITPQAKERVCNLI
376	NLIDSGTKEGASILL
47	VKLFIGGKFVESKSD
52	GGKFVESKSDKWIDI
55	FVESKSDKWIDIHNP
76	GRVPQATKAEMDAAI
87	DAAIASCKRAFPAWA

Function

Malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine

Protein Sequence

10 MAALLAAAAV 20 RARILQVSSK 30 VKSSPTWYSA 40 SSFSSSVPTV 50 KLFIGGKFVE 60 SKSDKWIDIH 70 NPATNEVIGR 80 VPQATKAEMD 90 AAIASCKRAF 100 PAWADTSVLS 110 RQQVLLRYQQ 120 LIKENLKEIA 130 KLITLEQGKT 140 LADAEGDVFR 150 GLQVVEHACS 160 VTSLMMGETM 170 PSITKDMDLY 180 SYRLPLGVCA 190 GIAPFNFPAM 200 IPLWMFPMAM 210 VCGNTFLMKP 220 SERVPGATML 230 LAKLLQDSGA 240 PDGTLNIIHG 250 QHEAVNFICD 260 HPDIKAISFV 270 GSNKAGEYIF 280 ERGSRHGKRV 290 QANMGAKNHG 300 VVMPDANKEN 310 TLNQLVGAAF 320 GAAGQRCMAL 330 STAVLVGEAK 340 KWLPELVEHA 350 KNLRVNAGDQ 360 PGADLGPLIT 370 PQAKERVCNL 380 IDSGTKEGAS 390 ILLDGRKIKV 400 KGYENGNFVG 410 PTIISNVKPN 420 MTCYKEEIFG 430 PVLVVLETET 440 LDEAIQIVNN 450 NPYGNGTAIF 460 TTNGATARKY 470 AHLVDVGQVG 480 VNVPIPVPLP 490 MFSFTGSRSS 500 FRGDTNFYGK 510 QGIQFYTQLK 520 TITSQWKEED 530 ATLSSPAVVM PTMGR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0004491	methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0009083	branched-chain amino acid catabolic process
Biological Process	GO:0006574	L-valine catabolic process
Biological Process	GO:0006210	thymine catabolic process
Biological Process	GO:0019859	thymine metabolic process
Biological Process	GO:0006573	valine metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.