Search Results
Overview
| Uniprot ID | Q02253 |
|---|---|
| Protein Name | Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial |
| Gene Name | Aldh6a1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 117 | QLIKENLKEIARLIT |
| 47 | VKLFIDGKFVESKSD |
| 76 | GRVPQSTKAEMEAAV |
Function
Malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine
Protein Sequence
10
MAAAVAAAAA
20
VRSRILQVSS
30
KVNSTWYPAS
40
SFSSSSVPTV
50
KLFIDGKFVE
60
SKSDKWIDIH
70
NPATNEVVGR
80
VPQSTKAEME
90
AAVAACKRAF
100
PAWADTSILS
110
RQQVLLRYQQ
120
LIKENLKEIA
130
RLITLEQGKT
140
LADAEGDVFR
150
GLQVVEHACS
160
VTSLMLGETM
170
PSITKDMDLY
180
SYRLPLGVCA
190
GIAPFNFPAM
200
IPLWMFPMAM
210
VCGNTFLMKP
220
SERVPGATML
230
LAKLLQDSGA
240
PDGTLNIIHG
250
QHEAVNFICD
260
HPDIKAISFV
270
GSNQAGEYIF
280
ERGSRNGKRV
290
QANMGAKNHG
300
VVMPDANKEN
310
TLNQLVGAAF
320
GAAGQRCMAL
330
STAVLVGEAK
340
KWLPELVERA
350
KNLRVNAGDQ
360
PGADLGPLIT
370
PQAKERVCNL
380
IDSGAKEGAS
390
ILLDGRKIKV
400
KGYENGNFVG
410
PTIISNVKPS
420
MTCYKEEIFG
430
PVLVVLETET
440
LDEAIKIVND
450
NPYGNGTAIF
460
TTNGAIARKY
470
AHMVDVGQVG
480
VNVPIPVPLP
490
MFSFTGSRSS
500
FRGDTNFYGK
510
QGIQFYTQLK
520
TITSQWKEED
530
ATLSSPAVVM
PTMGR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004491 | methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity |
| Molecular Function | GO:0016790 | thiolester hydrolase activity |
| Biological Process | GO:0019484 | beta-alanine catabolic process |
| Biological Process | GO:0050873 | brown fat cell differentiation |
| Biological Process | GO:0006574 | L-valine catabolic process |
| Biological Process | GO:0006210 | thymine catabolic process |
| Biological Process | GO:0019859 | thymine metabolic process |
| Biological Process | GO:0006573 | valine metabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.