Search Results
Overview
| Uniprot ID | Q02383 |
|---|---|
| Protein Name | Semenogelin-2 |
| Gene Name | SEMG2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 110 | SQQLLNYKQEGRDHD |
| 120 | GRDHDKSKGHFHMIV |
| 131 | HMIVIHHKGGQAHHG |
| 153 | QGNSPSGKGLSSQCS |
| 164 | SQCSNTEKRLWVHGL |
| 173 | LWVHGLSKEQASASG |
| 183 | ASASGAQKGRTQGGS |
| 205 | TEELVVNKQQRETKN |
| 217 | TKNSHQNKGHYQNVV |
| 285 | EHGRKAHKISYPSSR |
| 307 | HGEKSVQKDVSKGSI |
| 321 | ISIQTEEKIHGKSQN |
| 363 | RHLNCGEKGIQKGVS |
| 367 | CGEKGIQKGVSKGSI |
| 431 | DVQKGVSKGSISIQT |
| 44 | SQFPHGQKGQHYFGQ |
| 441 | ISIQTEEKIHGKSQN |
| 487 | YGGKSTQKDVSQSSI |
| 52 | GQHYFGQKDQQHTKS |
| 543 | DLLSHEQKGRYKQES |
| 58 | QKDQQHTKSKGSFSI |
| 60 | DQQHTKSKGSFSIQH |
| 81 | NDHDWTRKSQQYDLN |
| 92 | YDLNALHKATKSKQH |
| 97 | LHKATKSKQHLGGSQ |
Function
Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa
Protein Sequence
10
MKSIILFVLS
20
LLLILEKQAA
30
VMGQKGGSKG
40
QLPSGSSQFP
50
HGQKGQHYFG
60
QKDQQHTKSK
70
GSFSIQHTYH
80
VDINDHDWTR
90
KSQQYDLNAL
100
HKATKSKQHL
110
GGSQQLLNYK
120
QEGRDHDKSK
130
GHFHMIVIHH
140
KGGQAHHGTQ
150
NPSQDQGNSP
160
SGKGLSSQCS
170
NTEKRLWVHG
180
LSKEQASASG
190
AQKGRTQGGS
200
QSSYVLQTEE
210
LVVNKQQRET
220
KNSHQNKGHY
230
QNVVDVREEH
240
SSKLQTSLHP
250
AHQDRLQHGP
260
KDIFTTQDEL
270
LVYNKNQHQT
280
KNLSQDQEHG
290
RKAHKISYPS
300
SRTEERQLHH
310
GEKSVQKDVS
320
KGSISIQTEE
330
KIHGKSQNQV
340
TIHSQDQEHG
350
HKENKISYQS
360
SSTEERHLNC
370
GEKGIQKGVS
380
KGSISIQTEE
390
QIHGKSQNQV
400
RIPSQAQEYG
410
HKENKISYQS
420
SSTEERRLNS
430
GEKDVQKGVS
440
KGSISIQTEE
450
KIHGKSQNQV
460
TIPSQDQEHG
470
HKENKMSYQS
480
SSTEERRLNY
490
GGKSTQKDVS
500
QSSISFQIEK
510
LVEGKSQIQT
520
PNPNQDQWSG
530
QNAKGKSGQS
540
ADSKQDLLSH
550
EQKGRYKQES
560
SESHNIVITE
570
HEVAQDDHLT
580
QQYNEDRNPI
ST
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001669 | acrosomal vesicle |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0002020 | protease binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0019731 | antibacterial humoral response |
| Biological Process | GO:0050817 | coagulation |
| Biological Process | GO:1901318 | negative regulation of flagellated sperm motility |
| Biological Process | GO:1900005 | positive regulation of serine-type endopeptidase activity |
| Biological Process | GO:0048240 | sperm capacitation |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.