Search Results
Overview
| Uniprot ID | Q02410 |
|---|---|
| Protein Name | Amyloid-beta A4 precursor protein-binding family A member 1 |
| Gene Name | APBA1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 354 | SLAIKDIKEAIEEVK |
Function
Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity)
Protein Sequence
10
MNHLEGSAEV
20
EVTDEAAGGE
30
VNESVEADLE
40
HPEVEEEQQQ
50
PPQQQHYVGR
60
HQRGRALEDL
70
RAQLGQEEEE
80
RGECLARSAS
90
TESGFHNHTD
100
TAEGDVIAAA
110
RDGYDAERAQ
120
DPEDESAYAV
130
QYRPEAEEYT
140
EQAEAEHAEA
150
THRRALPNHL
160
HFHSLEHEEA
170
MNAAYSGYVY
180
THRLFHRGED
190
EPYSEPYADY
200
GGLQEHVYEE
210
IGDAPELDAR
220
DGLRLYEQER
230
DEAAAYRQEA
240
LGARLHHYDE
250
RSDGESDSPE
260
KEAEFAPYPR
270
MDSYEQEEDI
280
DQIVAEVKQS
290
MSSQSLDKAA
300
EDMPEAEQDL
310
ERPPTPAGGR
320
PDSPGLQAPA
330
GQQRAVGPAG
340
GGEAGQRYSK
350
EKRDAISLAI
360
KDIKEAIEEV
370
KTRTIRSPYT
380
PDEPKEPIWV
390
MRQDISPTRD
400
CDDQRPMDGD
410
SPSPGSSSPL
420
GAESSSTSLH
430
PSDPVEASTN
440
KESRKSLASF
450
PTYVEVPGPC
460
DPEDLIDGII
470
FAANYLGSTQ
480
LLSDKTPSKN
490
VRMMQAQEAV
500
SRIKMAQKLA
510
KSRKKAPEGE
520
SQPMTEVDLF
530
ISTQRIKVLN
540
ADTQETMMDH
550
PLRTISYIAD
560
IGNIVVLMAR
570
RRMPRSNSQE
580
NVEASHPSQD
590
GKRQYKMICH
600
VFESEDAQLI
610
AQSIGQAFSV
620
AYQEFLRANG
630
INPEDLSQKE
640
YSDLLNTQDM
650
YNDDLIHFSK
660
SENCKDVFIE
670
KQKGEILGVV
680
IVESGWGSIL
690
PTVIIANMMH
700
GGPAEKSGKL
710
NIGDQIMSIN
720
GTSLVGLPLS
730
TCQSIIKGLK
740
NQSRVKLNIV
750
RCPPVTTVLI
760
RRPDLRYQLG
770
FSVQNGIICS
780
LMRGGIAERG
790
GVRVGHRIIE
800
INGQSVVATP
810
HEKIVHILSN
820
AVGEIHMKTM
830
PAAMYRLLTA
QEQPVYI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0048787 | presynaptic active zone membrane |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Molecular Function | GO:0001540 | amyloid-beta binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Biological Process | GO:0008088 | axo-dendritic transport |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0099171 | presynaptic modulation of chemical synaptic transmission |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0065003 | protein-containing complex assembly |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.