Search Results
Overview
| Uniprot ID | Q02447 |
|---|---|
| Protein Name | Transcription factor Sp3 |
| Gene Name | SP3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 593 | DQQHQEGKRLRRVAC |
Function
Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping
Protein Sequence
10
MTAPEKPVKQ
20
EEMAALDVDS
30
GGGGGGGGGH
40
GEYLQQQQQH
50
GNGAVAAAAA
60
AQDTQPSPLA
70
LLAATCSKIG
80
PPSPGDDEEE
90
AAAAAGAPAA
100
AGATGDLASA
110
QLGGAPNRWE
120
VLSATPTTIK
130
DEAGNLVQIP
140
SAATSSGQYV
150
LPLQNLQNQQ
160
IFSVAPGSDS
170
SNGTVSSVQY
180
QVIPQIQSAD
190
GQQVQIGFTG
200
SSDNGGINQE
210
SSQIQIIPGS
220
NQTLLASGTP
230
SANIQNLIPQ
240
TGQVQVQGVA
250
IGGSSFPGQT
260
QVVANVPLGL
270
PGNITFVPIN
280
SVDLDSLGLS
290
GSSQTMTAGI
300
NADGHLINTG
310
QAMDSSDNSE
320
RTGERVSPDI
330
NETNTDTDLF
340
VPTSSSSQLP
350
VTIDSTGILQ
360
QNTNSLTTSS
370
GQVHSSDLQG
380
NYIQSPVSEE
390
TQAQNIQVST
400
AQPVVQHLQL
410
QESQQPTSQA
420
QIVQGITPQT
430
IHGVQASGQN
440
ISQQALQNLQ
450
LQLNPGTFLI
460
QAQTVTPSGQ
470
VTWQTFQVQG
480
VQNLQNLQIQ
490
NTAAQQITLT
500
PVQTLTLGQV
510
AAGGAFTSTP
520
VSLSTGQLPN
530
LQTVTVNSID
540
SAGIQLHPGE
550
NADSPADIRI
560
KEEEPDPEEW
570
QLSGDSTLNT
580
NDLTHLRVQV
590
VDEEGDQQHQ
600
EGKRLRRVAC
610
TCPNCKEGGG
620
RGTNLGKKKQ
630
HICHIPGCGK
640
VYGKTSHLRA
650
HLRWHSGERP
660
FVCNWMYCGK
670
RFTRSDELQR
680
HRRTHTGEKK
690
FVCPECSKRF
700
MRSDHLAKHI
710
KTHQNKKGIH
720
SSSTVLASVE
730
AARDDTLITA
740
GGTTLILANI
750
QQGSVSGIGT
760
VNTSATSNQD
770
ILTNTEIPLQ
780
LVTVSGNETM
E
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0016605 | PML body |
| Cellular Component | GO:0032993 | protein-DNA complex |
| Cellular Component | GO:0017053 | transcription repressor complex |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.