Search Results
Overview
| Uniprot ID | Q02539 |
|---|---|
| Protein Name | Histone H1.1 |
| Gene Name | H1-1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 100 | KGTLVQTKGTGASGS |
| 125 | ETKPGASKVATKTKA |
| 129 | GASKVATKTKATGAS |
Function
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber (PubMed:11130728). Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex (PubMed:11130728). Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity)
Protein Sequence
10
MSETVPPAPA
20
ASAAPEKPLA
30
GKKAKKPAKA
40
AAASKKKPAG
50
PSVSELIVQA
60
ASSSKERGGV
70
SLAALKKALA
80
AAGYDVEKNN
90
SRIKLGIKSL
100
VSKGTLVQTK
110
GTGASGSFKL
120
NKKASSVETK
130
PGASKVATKT
140
KATGASKKLK
150
KATGASKKSV
160
KTPKKAKKPA
170
ATRKSSKNPK
180
KPKTVKPKKV
190
AKSPAKAKAV
200
KPKAAKARVT
210
KPKTAKPKKA
APKKK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0000791 | euchromatin |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0000786 | nucleosome |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0031982 | vesicle |
| Molecular Function | GO:0031490 | chromatin DNA binding |
| Molecular Function | GO:0003690 | double-stranded DNA binding |
| Molecular Function | GO:0008201 | heparin binding |
| Molecular Function | GO:0031492 | nucleosomal DNA binding |
| Molecular Function | GO:0030527 | structural constituent of chromatin |
| Biological Process | GO:0030261 | chromosome condensation |
| Biological Process | GO:0045910 | negative regulation of DNA recombination |
| Biological Process | GO:0006334 | nucleosome assembly |
| Biological Process | GO:0048260 | positive regulation of receptor-mediated endocytosis |
| Biological Process | GO:0007283 | spermatogenesis |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.