Search Results
Overview
| Uniprot ID | Q02563 |
|---|---|
| Protein Name | Synaptic vesicle glycoprotein 2A |
| Gene Name | Sv2a |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 109 | PRAESGGKGERMADG |
| 32 | HAAKKVVKGLDRVQD |
| 385 | HDTNMRAKGHPERVF |
Function
Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles
Protein Sequence
10
MEEGFRDRAA
20
FIRGAKDIAK
30
EVKKHAAKKV
40
VKGLDRVQDE
50
YSRRSYSRFE
60
EEEDDDDFPA
70
PADGYYRGEG
80
AQDEEEGGAS
90
SDATEGHDED
100
DEIYEGEYQG
110
IPRAESGGKG
120
ERMADGAPLA
130
GVRGGLSDGE
140
GPPGGRGEAQ
150
RRKDREELAQ
160
QYETILRECG
170
HGRFQWTLYF
180
VLGLALMADG
190
VEVFVVGFVL
200
PSAEKDMCLS
210
DSNKGMLGLI
220
VYLGMMVGAF
230
LWGGLADRLG
240
RRQCLLISLS
250
VNSVFAFFSS
260
FVQGYGTFLF
270
CRLLSGVGIG
280
GSIPIVFSYF
290
SEFLAQEKRG
300
EHLSWLCMFW
310
MIGGVYAAAM
320
AWAIIPHYGW
330
SFQMGSAYQF
340
HSWRVFVLVC
350
AFPSVFAIGA
360
LTTQPESPRF
370
FLENGKHDEA
380
WMVLKQVHDT
390
NMRAKGHPER
400
VFSVTHIKTI
410
HQEDELIEIQ
420
SDTGTWYQRW
430
GVRALSLGGQ
440
VWGNFLSCFS
450
PEYRRITLMM
460
MGVWFTMSFS
470
YYGLTVWFPD
480
MIRHLQAVDY
490
AARTKVFPGE
500
RVEHVTFNFT
510
LENQIHRGGQ
520
YFNDKFIGLR
530
LKSVSFEDSL
540
FEECYFEDVT
550
SSNTFFRNCT
560
FINTVFYNTD
570
LFEYKFVNSR
580
LVNSTFLHNK
590
EGCPLDVTGT
600
GEGAYMVYFV
610
SFLGTLAVLP
620
GNIVSALLMD
630
KIGRLRMLAG
640
SSVLSCVSCF
650
FLSFGNSESA
660
MIALLCLFGG
670
VSIASWNALD
680
VLTVELYPSD
690
KRTTAFGFLN
700
ALCKLAAVLG
710
ISIFTSFVGI
720
TKAAPILFAS
730
AALALGSSLA
740
LKLPETRGQV
LQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0098982 | GABA-ergic synapse |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0048786 | presynaptic active zone |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Cellular Component | GO:0043195 | terminal bouton |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0022857 | transmembrane transporter activity |
| Biological Process | GO:0006874 | intracellular calcium ion homeostasis |
| Biological Process | GO:0098828 | modulation of inhibitory postsynaptic potential |
| Biological Process | GO:0090394 | negative regulation of excitatory postsynaptic potential |
| Biological Process | GO:0006836 | neurotransmitter transport |
| Biological Process | GO:0035418 | protein localization to synapse |
| Biological Process | GO:0014052 | regulation of gamma-aminobutyric acid secretion |
| Biological Process | GO:0016082 | synaptic vesicle priming |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.