Search Results

Overview

Uniprot IDQ02566
Protein NameMyosin-6
Gene NameMyh6
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
1024 DKVNTLTKSKVKLEQ
1028 TLTKSKVKLEQQVDD
1056 DLERAKRKLEGDLKL
1085 LEEKLKKKEFDISQQ
1108 ALALQLQKKLKENQA
1167 SVQIEMNKKREAEFQ
1175 KREAEFQKMRRDLEE
1197 TAAALRKKHADSVAE
1249 KAKANLEKVSRTLED
1264 QANEYRVKLEEAQRS
1281 DFTTQRAKLQTENGE
1307 ISQLTRGKLSYTQQM
1318 TQQMEDLKRQLEEEG
1326 RQLEEEGKAKNALAH
1356 YEEEMEAKAELQRVL
1365 ELQRVLSKANSEVAQ
1376 EVAQWRTKYETDAIQ
1392 TEELEEAKKKLAQRL
1412 AVEAVNAKCSSLEKT
1418 AKCSSLEKTKHRLQN
1446 AAAAALDKKQRNFDK
1453 KKQRNFDKILAEWKQ
1461 ILAEWKQKYEESQSE
1474 SELESSQKEARSLST
1487 STELFKLKNAYEESL
1501 LEHLETFKRENKNLQ
1530 KNVHELEKIRKQLEV
1571 QLEFNQIKAEIERKL
1577 IKAEIERKLAEKDEE
1581 IERKLAEKDEEMEQA
1589 DEEMEQAKRNHLRMV
1643 RIASEAQKHLKNSQA
1653 KNSQAHLKDTQLQLD
1702 EQTERSRKLAEQELI
1729 NTSLINQKKKMESDL
1759 NAEEKAKKAITDAAM
1772 AMMAEELKKEQDTSA
1773 MMAEELKKEQDTSAH
1786 AHLERMKKNMEQTIK
1793 KNMEQTIKDLQHRLD
1833 NELEAEQKRNAESVK
1840 KRNAESVKGMRKSER
1850 RKSERRIKELTYQTE
1860 TYQTEEDKKNLMRLQ
1872 RLQDLVDKLQLKVKA
1897 QANTNLSKFRKVQHE
1900 TNLSKFRKVQHELDE
1921 IAESQVNKLRAKSRD
279 SRVIFQLKAERNYHI
406 GLCHPRVKVGNEYVT
43 ECFVPDDKEEYVKAK
451 INATLETKQPRQYFI
48 DDKEEYVKAKVVSRE
503 VLEQEEYKKEGIEWE
560 LYDNHLGKSNNFQKP
566 GKSNNFQKPRNVKGK
58 VVSREGGKVTAETEN
599 MGWLEKNKDPLNETV
612 TVVGLYQKSSLKLMA
642 KGKGGKKKGSSFQTV
659 LHRENLNKLMTNLKT
665 NKLMTNLKTTHPHFV
67 TAETENGKTVTIKED
681 CIIPNERKAPGVMDN
72 NGKTVTIKEDQVMQQ
746 DSRKGAEKLLGSLDI
759 DIDHNQYKFGHTKVF
764 QYKFGHTKVFFKAGL
83 VMQQNPPKFDKIEDM
837 PWMKLYFKIKPLLKS
843 FKIKPLLKSAETEKE
849 LKSAETEKEMANMKE
855 EKEMANMKEEFGRVK
867 RVKDALEKSEARRKE
878 RRKELEEKMVSLLQE
912 ERCDQLIKNKIQLEA
914 CDQLIKNKIQLEAKV
922 IQLEAKVKEMTERLE
941 MNAELTAKKRKLEDE
944 ELTAKKRKLEDECSE
953 EDECSELKKDIDDLE
954 DECSELKKDIDDLEL
978 HATENKVKNLTEEMA

Function

Muscle contraction

Protein Sequence

10 MTDAQMADFG 20 AAAQYLRKSE 30 KERLEAQTRP 40 FDIRTECFVP 50 DDKEEYVKAK 60 VVSREGGKVT 70 AETENGKTVT 80 IKEDQVMQQN 90 PPKFDKIEDM 100 AMLTFLHEPA 110 VLYNLKERYA 120 AWMIYTYSGL 130 FCVTVNPYKW 140 LPVYNAEVVA 150 AYRGKKRSEA 160 PPHIFSISDN 170 AYQYMLTDRE 180 NQSILITGES 190 GAGKTVNTKR 200 VIQYFASIAA 210 IGDRSKKENP 220 NANKGTLEDQ 230 IIQANPALEA 240 FGNAKTVRND 250 NSSRFGKFIR 260 IHFGATGKLA 270 SADIETYLLE 280 KSRVIFQLKA 290 ERNYHIFYQI 300 LSNKKPELLD 310 MLLVTNNPYD 320 YAFVSQGEVS 330 VASIDDSEEL 340 LATDSAFDVL 350 SFTAEEKAGV 360 YKLTGAIMHY 370 GNMKFKQKQR 380 EEQAEPDGTE 390 DADKSAYLMG 400 LNSADLLKGL 410 CHPRVKVGNE 420 YVTKGQSVQQ 430 VYYSIGALAK 440 SVYEKMFNWM 450 VTRINATLET 460 KQPRQYFIGV 470 LDIAGFEIFD 480 FNSFEQLCIN 490 FTNEKLQQFF 500 NHHMFVLEQE 510 EYKKEGIEWE 520 FIDFGMDLQA 530 CIDLIEKPMG 540 IMSILEEECM 550 FPKASDMTFK 560 AKLYDNHLGK 570 SNNFQKPRNV 580 KGKQEAHFSL 590 VHYAGTVDYN 600 IMGWLEKNKD 610 PLNETVVGLY 620 QKSSLKLMAT 630 LFSTYASADT 640 GDSGKGKGGK 650 KKGSSFQTVS 660 ALHRENLNKL 670 MTNLKTTHPH 680 FVRCIIPNER 690 KAPGVMDNPL 700 VMHQLRCNGV 710 LEGIRICRKG 720 FPNRILYGDF 730 RQRYRILNPA 740 AIPEGQFIDS 750 RKGAEKLLGS 760 LDIDHNQYKF 770 GHTKVFFKAG 780 LLGLLEEMRD 790 ERLSRIITRI 800 QAQARGQLMR 810 IEFKKIVERR 820 DALLVIQWNI 830 RAFMGVKNWP 840 WMKLYFKIKP 850 LLKSAETEKE 860 MANMKEEFGR 870 VKDALEKSEA 880 RRKELEEKMV 890 SLLQEKNDLQ 900 LQVQAEQDNL 910 NDAEERCDQL 920 IKNKIQLEAK 930 VKEMTERLED 940 EEEMNAELTA 950 KKRKLEDECS 960 ELKKDIDDLE 970 LTLAKVEKEK 980 HATENKVKNL 990 TEEMAGLDEI 1000 IAKLTKEKKA 1010 LQEAHQQALD 1020 DLQAEEDKVN 1030 TLTKSKVKLE 1040 QQVDDLEGSL 1050 EQEKKVRMDL 1060 ERAKRKLEGD 1070 LKLTQESIMD 1080 LENDKLQLEE 1090 KLKKKEFDIS 1100 QQNSKIEDEQ 1110 ALALQLQKKL 1120 KENQARIEEL 1130 EEELEAERTA 1140 RAKVEKLRSD 1150 LSRELEEISE 1160 RLEEAGGATS 1170 VQIEMNKKRE 1180 AEFQKMRRDL 1190 EEATLQHEAT 1200 AAALRKKHAD 1210 SVAELGEQID 1220 NLQRVKQKLE 1230 KEKSEFKLEL 1240 DDVTSNMEQI 1250 IKAKANLEKV 1260 SRTLEDQANE 1270 YRVKLEEAQR 1280 SLNDFTTQRA 1290 KLQTENGELA 1300 RQLEEKEALI 1310 SQLTRGKLSY 1320 TQQMEDLKRQ 1330 LEEEGKAKNA 1340 LAHALQSSRH 1350 DCDLLREQYE 1360 EEMEAKAELQ 1370 RVLSKANSEV 1380 AQWRTKYETD 1390 AIQRTEELEE 1400 AKKKLAQRLQ 1410 DAEEAVEAVN 1420 AKCSSLEKTK 1430 HRLQNEIEDL 1440 MVDVERSNAA 1450 AAALDKKQRN 1460 FDKILAEWKQ 1470 KYEESQSELE 1480 SSQKEARSLS 1490 TELFKLKNAY 1500 EESLEHLETF 1510 KRENKNLQEE 1520 ISDLTEQLGE 1530 GGKNVHELEK 1540 IRKQLEVEKL 1550 ELQSALEEAE 1560 ASLEHEEGKI 1570 LRAQLEFNQI 1580 KAEIERKLAE 1590 KDEEMEQAKR 1600 NHLRMVDSLQ 1610 TSLDAETRSR 1620 NEALRVKKKM 1630 EGDLNEMEIQ 1640 LSQANRIASE 1650 AQKHLKNSQA 1660 HLKDTQLQLD 1670 DAVHANDDLK 1680 ENIAIVERRN 1690 NLLQAELEEL 1700 RAVVEQTERS 1710 RKLAEQELIE 1720 TSERVQLLHS 1730 QNTSLINQKK 1740 KMESDLTQLQ 1750 TEVEEAVQEC 1760 RNAEEKAKKA 1770 ITDAAMMAEE 1780 LKKEQDTSAH 1790 LERMKKNMEQ 1800 TIKDLQHRLD 1810 EAEQIALKGG 1820 KKQLQKLEAR 1830 VRELENELEA 1840 EQKRNAESVK 1850 GMRKSERRIK 1860 ELTYQTEEDK 1870 KNLMRLQDLV 1880 DKLQLKVKAY 1890 KRQAEEAEEQ 1900 ANTNLSKFRK 1910 VQHELDEAEE 1920 RADIAESQVN 1930 KLRAKSRDIG AKKMHDEE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005859 muscle myosin complex
Cellular Component GO:0030016 myofibril
Cellular Component GO:0016459 myosin complex
Cellular Component GO:0032982 myosin filament
Cellular Component GO:0016460 myosin II complex
Cellular Component GO:0001725 stress fiber
Cellular Component GO:0030018 Z disc
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0030899 calcium-dependent ATPase activity
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0000146 microfilament motor activity
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0044877 protein-containing complex binding
Biological Process GO:0030048 actin filament-based movement
Biological Process GO:0007512 adult heart development
Biological Process GO:0046034 ATP metabolic process
Biological Process GO:0055009 atrial cardiac muscle tissue morphogenesis
Biological Process GO:0055013 cardiac muscle cell development
Biological Process GO:0060048 cardiac muscle contraction
Biological Process GO:0014898 cardiac muscle hypertrophy in response to stress
Biological Process GO:0001701 in utero embryonic development
Biological Process GO:0006936 muscle contraction
Biological Process GO:0030049 muscle filament sliding
Biological Process GO:0030239 myofibril assembly
Biological Process GO:0043462 regulation of ATP-dependent activity
Biological Process GO:0008217 regulation of blood pressure
Biological Process GO:0008016 regulation of heart contraction
Biological Process GO:0060420 regulation of heart growth
Biological Process GO:0002027 regulation of heart rate
Biological Process GO:0002026 regulation of the force of heart contraction
Biological Process GO:0045214 sarcomere organization
Biological Process GO:0006941 striated muscle contraction
Biological Process GO:0055010 ventricular cardiac muscle tissue morphogenesis
Biological Process GO:0007522 visceral muscle development

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.