Search Results

Overview

Uniprot IDQ02790
Protein NamePeptidyl-prolyl cis-trans isomerase FKBP4
Gene NameFKBP4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
108 EVCHITCKPEYAYGS
181 LEGYYKDKLFDQREL
232 YAFGSVGKEKFQIPP
234 FGSVGKEKFQIPPNA
256 LKSFEKAKESWEMNS
274 LEQSTIVKERGTVYF
282 ERGTVYFKEGKYKQA
287 YFKEGKYKQALLQYK
294 KQALLQYKKIVSWLE
331 NLAMCHLKLQAFSAA
354 ELDSNNEKGLFRRGE
387 LQLYPNNKAAKTQLA
390 YPNNKAAKTQLAVCQ
409 RQLAREKKLYANMFE

Function

Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria

Protein Sequence

10 MTAEEMKATE 20 SGAQSAPLPM 30 EGVDISPKQD 40 EGVLKVIKRE 50 GTGTEMPMIG 60 DRVFVHYTGW 70 LLDGTKFDSS 80 LDRKDKFSFD 90 LGKGEVIKAW 100 DIAIATMKVG 110 EVCHITCKPE 120 YAYGSAGSPP 130 KIPPNATLVF 140 EVELFEFKGE 150 DLTEEEDGGI 160 IRRIQTRGEG 170 YAKPNEGAIV 180 EVALEGYYKD 190 KLFDQRELRF 200 EIGEGENLDL 210 PYGLERAIQR 220 MEKGEHSIVY 230 LKPSYAFGSV 240 GKEKFQIPPN 250 AELKYELHLK 260 SFEKAKESWE 270 MNSEEKLEQS 280 TIVKERGTVY 290 FKEGKYKQAL 300 LQYKKIVSWL 310 EYESSFSNEE 320 AQKAQALRLA 330 SHLNLAMCHL 340 KLQAFSAAIE 350 SCNKALELDS 360 NNEKGLFRRG 370 EAHLAVNDFE 380 LARADFQKVL 390 QLYPNNKAAK 400 TQLAVCQQRI 410 RRQLAREKKL 420 YANMFERLAE 430 EENKAKAEAS 440 SGDHPTDTEM 450 KEEQKSNTAG SQSQVETEA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0044295 axonal growth cone
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005874 microtubule
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0032767 copper-dependent protein binding
Molecular Function GO:0005528 FK506 binding
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0031072 heat shock protein binding
Molecular Function GO:0035259 nuclear glucocorticoid receptor binding
Molecular Function GO:0003755 peptidyl-prolyl cis-trans isomerase activity
Molecular Function GO:0051219 phosphoprotein binding
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0048156 tau protein binding
Biological Process GO:0006825 copper ion transport
Biological Process GO:0031115 negative regulation of microtubule polymerization
Biological Process GO:0031111 negative regulation of microtubule polymerization or depolymerization
Biological Process GO:0010977 negative regulation of neuron projection development
Biological Process GO:0006457 protein folding

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.