Search Results
Overview
| Uniprot ID | Q02818 |
|---|---|
| Protein Name | Nucleobindin-1 |
| Gene Name | NUCB1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 71 | TDGHFREKLQAANAE |
Function
Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity)
Protein Sequence
10
MPPSGPRGTL
20
LLLPLLLLLL
30
LRAVLAVPLE
40
RGAPNKEETP
50
ATESPDTGLY
60
YHRYLQEVID
70
VLETDGHFRE
80
KLQAANAEDI
90
KSGKLSRELD
100
FVSHHVRTKL
110
DELKRQEVSR
120
LRMLLKAKMD
130
AEQDPNVQVD
140
HLNLLKQFEH
150
LDPQNQHTFE
160
ARDLELLIQT
170
ATRDLAQYDA
180
AHHEEFKRYE
190
MLKEHERRRY
200
LESLGEEQRK
210
EAERKLEEQQ
220
RRHREHPKVN
230
VPGSQAQLKE
240
VWEELDGLDP
250
NRFNPKTFFI
260
LHDINSDGVL
270
DEQELEALFT
280
KELEKVYDPK
290
NEEDDMREME
300
EERLRMREHV
310
MKNVDTNQDR
320
LVTLEEFLAS
330
TQRKEFGDTG
340
EGWETVEMHP
350
AYTEEELRRF
360
EEELAAREAE
370
LNAKAQRLSQ
380
ETEALGRSQG
390
RLEAQKRELQ
400
QAVLHMEQRK
410
QQQQQQQGHK
420
APAAHPEGQL
430
KFHPDTDDVP
440
VPAPAGDQKE
450
VDTSEKKLLE
460
RLPEVEVPQH
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0016020 | membrane |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0001965 | G-protein alpha-subunit binding |
| Molecular Function | GO:0005085 | guanyl-nucleotide exchange factor activity |
| Biological Process | GO:0007264 | small GTPase-mediated signal transduction |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.