Search Results

Overview

Uniprot ID	Q02952
Protein Name	A-kinase anchor protein 12
Gene Name	AKAP12
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1316	TEEAECKKDDALELQ
1493	VIVSATTKKGLSSDL
1494	IVSATTKKGLSSDLE
1509	GEKTTSLKWKSDEVD
177	IGFKKVFKFVGFKFT
467	AKELVKLKETCVSGE
517	KVQGSPLKKLFTSTG
518	VQGSPLKKLFTSTGL
526	LFTSTGLKKLSGKKQ
527	FTSTGLKKLSGKKQK

Function

Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC)

Protein Sequence

10 MGAGSSTEQR 20 SPEQPPEGSS 30 TPAEPEPSGG 40 GPSAEAAPDT 50 TADPAIAASD 60 PATKLLQKNG 70 QLSTINGVAE 80 QDELSLQEGD 90 LNGQKGALNG 100 QGALNSQEEE 110 EVIVTEVGQR 120 DSEDVSKRDS 130 DKEMATKSAV 140 VHDITDDGQE 150 ETPEIIEQIP 160 SSESNLEELT 170 QPTESQANDI 180 GFKKVFKFVG 190 FKFTVKKDKT 200 EKPDTVQLLT 210 VKKDEGEGAA 220 GAGDHKDPSL 230 GAGEAASKES 240 EPKQSTEKPE 250 ETLKREQSHA 260 EISPPAESGQ 270 AVEECKEEGE 280 EKQEKEPSKS 290 AESPTSPVTS 300 ETGSTFKKFF 310 TQGWAGWRKK 320 TSFRKPKEDE 330 VEASEKKKEQ 340 EPEKVDTEED 350 GKAEVASEKL 360 TASEQAHPQE 370 PAESAHEPRL 380 SAEYEKVELP 390 SEEQVSGSQG 400 PSEEKPAPLA 410 TEVFDEKIEV 420 HQEEVVAEVH 430 VSTVEERTEE 440 QKTEVEETAG 450 SVPAEELVEM 460 DAEPQEAEPA 470 KELVKLKETC 480 VSGEDPTQGA 490 DLSPDEKVLS 500 KPPEGVVSEV 510 EMLSSQERMK 520 VQGSPLKKLF 530 TSTGLKKLSG 540 KKQKGKRGGG 550 DEESGEHTQV 560 PADSPDSQEE 570 QKGESSASSP 580 EEPEEITCLE 590 KGLAEVQQDG 600 EAEEGATSDG 610 EKKREGVTPW 620 ASFKKMVTPK 630 KRVRRPSESD 640 KEDELDKVKS 650 ATLSSTESTA 660 SEMQEEMKGS 670 VEEPKPEEPK 680 RKVDTSVSWE 690 ALICVGSSKK 700 RARRGSSSDE 710 EGGPKAMGGD 720 HQKADEAGKD 730 KETGTDGILA 740 GSQEHDPGQG 750 SSSPEQAGSP 760 TEGEGVSTWE 770 SFKRLVTPRK 780 KSKSKLEEKS 790 EDSIAGSGVE 800 HSTPDTEPGK 810 EESWVSIKKF 820 IPGRRKKRPD 830 GKQEQAPVED 840 AGPTGANEDD 850 SDVPAVVPLS 860 EYDAVEREKM 870 EAQQAQKSAE 880 QPEQKAATEV 890 SKELSESQVH 900 MMAAAVADGT 910 RAATIIEERS 920 PSWISASVTE 930 PLEQVEAEAA 940 LLTEEVLERE 950 VIAEEEPPTV 960 TEPLPENREA 970 RGDTVVSEAE 980 LTPEAVTAAE 990 TAGPLGAEEG 1000 TEASAAEETT 1010 EMVSAVSQLT 1020 DSPDTTEEAT 1030 PVQEVEGGVP 1040 DIEEQERRTQ 1050 EVLQAVAEKV 1060 KEESQLPGTG 1070 GPEDVLQPVQ 1080 RAEAERPEEQ 1090 AEASGLKKET 1100 DVVLKVDAQE 1110 AKTEPFTQGK 1120 VVGQTTPESF 1130 EKAPQVTESI 1140 ESSELVTTCQ 1150 AETLAGVKSQ 1160 EMVMEQAIPP 1170 DSVETPTDSE 1180 TDGSTPVADF 1190 DAPGTTQKDE 1200 IVEIHEENEV 1210 ASGTQSGGTE 1220 AEAVPAQKER 1230 PPAPSSFVFQ 1240 EETKEQSKME 1250 DTLEHTDKEV 1260 SVETVSILSK 1270 TEGTQEADQY 1280 ADEKTKDVPF 1290 FEGLEGSIDT 1300 GITVSREKVT 1310 EVALKGEGTE 1320 EAECKKDDAL 1330 ELQSHAKSPP 1340 SPVEREMVVQ 1350 VEREKTEAEP 1360 THVNEEKLEH 1370 ETAVTVSEEV 1380 SKQLLQTVNV 1390 PIIDGAKEVS 1400 SLEGSPPPCL 1410 GQEEAVCTKI 1420 QVQSSEASFT 1430 LTAAAEEEKV 1440 LGETANILET 1450 GETLEPAGAH 1460 LVLEEKSSEK 1470 NEDFAAHPGE 1480 DAVPTGPDCQ 1490 AKSTPVIVSA 1500 TTKKGLSSDL 1510 EGEKTTSLKW 1520 KSDEVDEQVA 1530 CQEVKVSVAI 1540 EDLEPENGIL 1550 ELETKSSKLV 1560 QNIIQTAVDQ 1570 FVRTEETATE 1580 MLTSELQTQA 1590 HVIKADSQDA 1600 GQETEKEGEE 1610 PQASAQDETP 1620 ITSAKEESES 1630 TAVGQAHSDI 1640 SKDMSEASEK 1650 TMTVEVEGST 1660 VNDQQLEEVV 1670 LPSEEEGGGA 1680 GTKSVPEDDG 1690 HALLAERIEK 1700 SLVEPKEDEK 1710 GDDVDDPENQ 1720 NSALADTDAS 1730 GGLTKESPDT 1740 NGPKQKEKED 1750 AQEVELQEGK 1760 VHSESDKAIT 1770 PQAQEELQKQ 1780 ERESAKSELT ES

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005938	cell cortex
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005856	cytoskeleton
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005925	focal adhesion
Cellular Component	GO:0043025	neuronal cell body
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse
Molecular Function	GO:0008179	adenylate cyclase binding
Molecular Function	GO:0005516	calmodulin binding
Molecular Function	GO:0051018	protein kinase A binding
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological Process	GO:0141156	cAMP/PKA signal transduction
Biological Process	GO:0071347	cellular response to interleukin-1
Biological Process	GO:0071356	cellular response to tumor necrosis factor
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway
Biological Process	GO:0035733	hepatic stellate cell activation
Biological Process	GO:0050804	modulation of chemical synaptic transmission
Biological Process	GO:0043116	negative regulation of vascular permeability
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade
Biological Process	GO:0061870	positive regulation of hepatic stellate cell migration
Biological Process	GO:1900143	positive regulation of oligodendrocyte apoptotic process
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production
Biological Process	GO:0090036	regulation of protein kinase C signaling
Biological Process	GO:0051602	response to electrical stimulus
Biological Process	GO:0032496	response to lipopolysaccharide
Biological Process	GO:0007165	signal transduction

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.