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Overview

Uniprot IDQ02978
Protein NameMitochondrial 2-oxoglutarate/malate carrier protein
Gene NameSLC25A11
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
15 GAGGIDGKPRTSPKS
260 IDGKPEYKNGLDVLF
57 QLSGEGAKTREYKTS
62 GAKTREYKTSFHALT
73 HALTSILKAEGLRGI

Function

Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate (PubMed:25637873, PubMed:38937634). Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity (By similarity). Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction (PubMed:38937634). Does not transport glutathione (PubMed:25637873). In addition can facilitate proton transport in the presence of protonophores such as long-chain fatty acids, contributing to mitochondrial uncoupling and regulation of mitochondrial energetic efficiency (By similarity). Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, gluconeogenesis from lactate, and nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (PubMed:21448454). Involved in the regulation of apoptosis (By similarity)

Protein Sequence

10 MAATASAGAG 20 GIDGKPRTSP 30 KSVKFLFGGL 40 AGMGATVFVQ 50 PLDLVKNRMQ 60 LSGEGAKTRE 70 YKTSFHALTS 80 ILKAEGLRGI 90 YTGLSAGLLR 100 QATYTTTRLG 110 IYTVLFERLT 120 GADGTPPGFL 130 LKAVIGMTAG 140 ATGAFVGTPA 150 EVALIRMTAD 160 GRLPADQRRG 170 YKNVFNALIR 180 ITREEGVLTL 190 WRGCIPTMAR 200 AVVVNAAQLA 210 SYSQSKQFLL 220 DSGYFSDNIL 230 CHFCASMISG 240 LVTTAASMPV 250 DIAKTRIQNM 260 RMIDGKPEYK 270 NGLDVLFKVV 280 RYEGFFSLWK 290 GFTPYYARLG 300 PHTVLTFIFL 310 EQMNKAYKRL FLSG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0015367 oxoglutarate:malate antiporter activity
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0022857 transmembrane transporter activity
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0043490 malate-aspartate shuttle

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.