Overview
| Uniprot ID | Q03013 |
|---|
| Protein Name | Glutathione S-transferase Mu 4 |
|---|
| Gene Name | GSTM4 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 83 |
ILCYIARKHNLCGET |
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:8203914, PubMed:8373352). Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 (PubMed:27791009). Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (PubMed:27791009)
Protein Sequence
10
MSMTLGYWDI
20
RGLAHAIRLL
30
LEYTDSSYEE
40
KKYTMGDAPD
50
YDRSQWLNEK
60
FKLGLDFPNL
70
PYLIDGAHKI
80
TQSNAILCYI
90
ARKHNLCGET
100
EEEKIRVDIL
110
ENQAMDVSNQ
120
LARVCYSPDF
130
EKLKPEYLEE
140
LPTMMQHFSQ
150
FLGKRPWFVG
160
DKITFVDFLA
170
YDVLDLHRIF
180
EPNCLDAFPN
190
LKDFISRFEG
200
LEKISAYMKS
210
SRFLPKPLYT
RVAVWGNK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Molecular Function |
GO:0019899 |
enzyme binding |
| Molecular Function |
GO:0043295 |
glutathione binding |
| Molecular Function |
GO:0004364 |
glutathione transferase activity |
| Molecular Function |
GO:0004464 |
leukotriene-C4 synthase activity |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Biological Process |
GO:0006749 |
glutathione metabolic process |
| Biological Process |
GO:0042759 |
long-chain fatty acid biosynthetic process |
| Biological Process |
GO:0042178 |
xenobiotic catabolic process |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.