Search Results
Overview
| Uniprot ID | Q03060 |
|---|---|
| Protein Name | cAMP-responsive element modulator |
| Gene Name | CREM |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 123 | SRRPSYRKILNELSS |
Function
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550)
Protein Sequence
10
MTMETVESQH
20
DGSITASLTE
30
SKSAHVQTQT
40
GQNSIPALAQ
50
VSVAGSGTRR
60
GSPAVTLVQL
70
PSGQTIHVQG
80
VIQTPQPWVI
90
QSSEIHTVQV
100
AAIAETDESA
110
ESEGVIDSHK
120
RREILSRRPS
130
YRKILNELSS
140
DVPGVPKIEE
150
ERSEEEGTPP
160
SIATMAVPTS
170
IYQTSTGQYI
180
AIAQGGTIQI
190
SNPGSDGVQG
200
LQALTMTNSG
210
APPPGATIVQ
220
YAAQSADGTQ
230
QFFVPGSQVV
240
VQDEETELAP
250
SHMAAATGDM
260
PTYQIRAPTA
270
ALPQGVVMAA
280
SPGSLHSPQQ
290
LAEEATRKRE
300
LRLMKNREAA
310
KECRRRKKEY
320
VKCLESRVAV
330
LEVQNKKLIE
340
ELETLKDICS
PKTDY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1990589 | ATF4-CREB1 transcription factor complex |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0008140 | cAMP response element binding protein binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Biological Process | GO:0141156 | cAMP/PKA signal transduction |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0048511 | rhythmic process |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0007283 | spermatogenesis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.