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Overview

Uniprot IDQ03112
Protein NameHistone-lysine N-methyltransferase MECOM
Gene NameMECOM
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
298 YKCDQCPKAFNWKSN
303 CPKAFNWKSNLIRHQ
787 RSRASGTKLTEPRKN

Function

Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis

Protein Sequence

10 MRSKGRARKL 20 ATNNECVYGN 30 YPEIPLEEMP 40 DADGVASTPS 50 LNIQEPCSPA 60 TSSEAFTPKE 70 GSPYKAPIYI 80 PDDIPIPAEF 90 ELRESNMPGA 100 GLGIWTKRKI 110 EVGEKFGPYV 120 GEQRSNLKDP 130 SYGWEILDEF 140 YNVKFCIDAS 150 QPDVGSWLKY 160 IRFAGCYDQH 170 NLVACQINDQ 180 IFYRVVADIA 190 PGEELLLFMK 200 SEDYPHETMA 210 PDIHEERQYR 220 CEDCDQLFES 230 KAELADHQKF 240 PCSTPHSAFS 250 MVEEDFQQKL 260 ESENDLQEIH 270 TIQECKECDQ 280 VFPDLQSLEK 290 HMLSHTEERE 300 YKCDQCPKAF 310 NWKSNLIRHQ 320 MSHDSGKHYE 330 CENCAKVFTD 340 PSNLQRHIRS 350 QHVGARAHAC 360 PECGKTFATS 370 SGLKQHKHIH 380 SSVKPFICEV 390 CHKSYTQFSN 400 LCRHKRMHAD 410 CRTQIKCKDC 420 GQMFSTTSSL 430 NKHRRFCEGK 440 NHFAAGGFFG 450 QGISLPGTPA 460 MDKTSMVNMS 470 HANPGLADYF 480 GANRHPAGLT 490 FPTAPGFSFS 500 FPGLFPSGLY 510 HRPPLIPASS 520 PVKGLSSTEQ 530 TNKSQSPLMT 540 HPQILPATQD 550 ILKALSKHPS 560 VGDNKPVELQ 570 PERSSEERPF 580 EKISDQSESS 590 DLDDVSTPSG 600 SDLETTSGSD 610 LESDIESDKE 620 KFKENGKMFK 630 DKVSPLQNLA 640 SINNKKEYSN 650 HSIFSPSLEE 660 QTAVSGAVND 670 SIKAIASIAE 680 KYFGSTGLVG 690 LQDKKVGALP 700 YPSMFPLPFF 710 PAFSQSMYPF 720 PDRDLRSLPL 730 KMEPQSPGEV 740 KKLQKGSSES 750 PFDLTTKRKD 760 EKPLTPVPSK 770 PPVTPATSQD 780 QPLDLSMGSR 790 SRASGTKLTE 800 PRKNHVFGGK 810 KGSNVESRPA 820 SDGSLQHARP 830 TPFFMDPIYR 840 VEKRKLTDPL 850 EALKEKYLRP 860 SPGFLFHPQM 870 SAIENMAEKL 880 ESFSALKPEA 890 SELLQSVPSM 900 FNFRAPPNAL 910 PENLLRKGKE 920 RYTCRYCGKI 930 FPRSANLTRH 940 LRTHTGEQPY 950 RCKYCDRSFS 960 ISSNLQRHVR 970 NIHNKEKPFK 980 CHLCDRCFGQ 990 QTNLDRHLKK 1000 HENGNMSGTA 1010 TSSPHSELES 1020 TGAILDDKED 1030 AYFTEIRNFI 1040 GNSNHGSQSP 1050 RNVEERMNGS 1060 HFKDEKALVT 1070 SQNSDLLDDE 1080 EVEDEVLLDE 1090 EDEDNDITGK 1100 TGKEPVTSNL 1110 HEGNPEDDYE 1120 ETSALEMSCK 1130 TSPVRYKEEE 1140 YKSGLSALDH 1150 IRHFTDSLKM 1160 RKMEDNQYSE 1170 AELSSFSTSH 1180 VPEELKQPLH 1190 RKSKSQAYAM 1200 MLSLSDKESL 1210 HSTSHSSSNV 1220 WHSMARAAAE 1230 SSAIQSISHV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0140938 histone H3 methyltransferase activity
Molecular Function GO:0046974 histone H3K9 methyltransferase activity
Molecular Function GO:0140948 histone H3K9 monomethyltransferase activity
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006915 apoptotic process
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0071425 hematopoietic stem cell proliferation
Biological Process GO:0070828 heterochromatin organization
Biological Process GO:0032259 methylation
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0046329 negative regulation of JNK cascade
Biological Process GO:0043069 negative regulation of programmed cell death
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0051604 protein maturation
Biological Process GO:0051726 regulation of cell cycle
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.