Search Results
Overview
| Uniprot ID | Q03135 |
|---|---|
| Protein Name | Caveolin-1 |
| Gene Name | CAV1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 5 | ***MSGGKYVDSEGH |
| 57 | DLVNRDPKHLNDDVV |
Function
May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity)
Protein Sequence
10
MSGGKYVDSE
20
GHLYTVPIRE
30
QGNIYKPNNK
40
AMADELSEKQ
50
VYDAHTKEID
60
LVNRDPKHLN
70
DDVVKIDFED
80
VIAEPEGTHS
90
FDGIWKASFT
100
TFTVTKYWFY
110
RLLSALFGIP
120
MALIWGIYFA
130
ILSFLHIWAV
140
VPCIKSFLIE
150
IQCISRVYSI
160
YVHTVCDPLF
170
EAVGKIFSNV
RINLQKEI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Cellular Component | GO:0002080 | acrosomal membrane |
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0005901 | caveola |
| Cellular Component | GO:0002095 | caveolar macromolecular signaling complex |
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005929 | cilium |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0031901 | early endosome membrane |
| Cellular Component | GO:0030666 | endocytic vesicle membrane |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0005811 | lipid droplet |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0042383 | sarcolemma |
| Molecular Function | GO:0051117 | ATPase binding |
| Molecular Function | GO:0015485 | cholesterol binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0070320 | inward rectifier potassium channel inhibitor activity |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Molecular Function | GO:0050998 | nitric-oxide synthase binding |
| Molecular Function | GO:0036487 | nitric-oxide synthase inhibitor activity |
| Molecular Function | GO:0008142 | oxysterol binding |
| Molecular Function | GO:0005113 | patched binding |
| Molecular Function | GO:0016504 | peptidase activator activity |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0140311 | protein sequestering activity |
| Molecular Function | GO:0030292 | protein tyrosine kinase inhibitor activity |
| Biological Process | GO:0032570 | response to progesterone |
| Biological Process | GO:0007519 | skeletal muscle tissue development |
| Biological Process | GO:0031295 | T cell costimulation |
| Biological Process | GO:0006641 | triglyceride metabolic process |
| Biological Process | GO:0001570 | vasculogenesis |
| Biological Process | GO:0016050 | vesicle organization |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Molecular Function | GO:0031267 | small GTPase binding |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Biological Process | GO:0038166 | angiotensin-activated signaling pathway |
| Biological Process | GO:0097190 | apoptotic signaling pathway |
| Biological Process | GO:0055074 | calcium ion homeostasis |
| Biological Process | GO:0006816 | calcium ion transport |
| Biological Process | GO:0060070 | canonical Wnt signaling pathway |
| Biological Process | GO:0070836 | caveola assembly |
| Biological Process | GO:0072584 | caveolin-mediated endocytosis |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0071455 | cellular response to hyperoxia |
| Biological Process | GO:0071218 | cellular response to misfolded protein |
| Biological Process | GO:0071375 | cellular response to peptide hormone stimulus |
| Biological Process | GO:0009267 | cellular response to starvation |
| Biological Process | GO:0042632 | cholesterol homeostasis |
| Biological Process | GO:0030301 | cholesterol transport |
| Biological Process | GO:0038016 | insulin receptor internalization |
| Biological Process | GO:0006874 | intracellular calcium ion homeostasis |
| Biological Process | GO:0033484 | intracellular nitric oxide homeostasis |
| Biological Process | GO:0008104 | intracellular protein localization |
| Biological Process | GO:0019915 | lipid storage |
| Biological Process | GO:0032507 | maintenance of protein location in cell |
| Biological Process | GO:0030879 | mammary gland development |
| Biological Process | GO:0060056 | mammary gland involution |
| Biological Process | GO:0051899 | membrane depolarization |
| Biological Process | GO:2000811 | negative regulation of anoikis |
| Biological Process | GO:0030514 | negative regulation of BMP signaling pathway |
| Biological Process | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0001937 | negative regulation of endothelial cell proliferation |
| Biological Process | GO:0030857 | negative regulation of epithelial cell differentiation |
| Biological Process | GO:0043409 | negative regulation of MAPK cascade |
| Biological Process | GO:0060546 | negative regulation of necroptotic process |
| Biological Process | GO:0045019 | negative regulation of nitric oxide biosynthetic process |
| Biological Process | GO:0048550 | negative regulation of pinocytosis |
| Biological Process | GO:1901380 | negative regulation of potassium ion transmembrane transport |
| Biological Process | GO:0031397 | negative regulation of protein ubiquitination |
| Biological Process | GO:0046426 | negative regulation of receptor signaling pathway via JAK-STAT |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0046209 | nitric oxide metabolic process |
| Biological Process | GO:0010524 | positive regulation of calcium ion transport into cytosol |
| Biological Process | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:0010875 | positive regulation of cholesterol efflux |
| Biological Process | GO:0120162 | positive regulation of cold-induced thermogenesis |
| Biological Process | GO:1904294 | positive regulation of ERAD pathway |
| Biological Process | GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway |
| Biological Process | GO:1903598 | positive regulation of gap junction assembly |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway |
| Biological Process | GO:0031398 | positive regulation of protein ubiquitination |
| Biological Process | GO:0045907 | positive regulation of vasoconstriction |
| Biological Process | GO:0010608 | post-transcriptional regulation of gene expression |
| Biological Process | GO:1903361 | protein localization to basolateral plasma membrane |
| Biological Process | GO:0044860 | protein localization to plasma membrane raft |
| Biological Process | GO:0031623 | receptor internalization |
| Biological Process | GO:0019065 | receptor-mediated endocytosis of virus by host cell |
| Biological Process | GO:0030193 | regulation of blood coagulation |
| Biological Process | GO:0098909 | regulation of cardiac muscle cell action potential involved in regulation of contraction |
| Biological Process | GO:1901844 | regulation of cell communication by electrical coupling involved in cardiac conduction |
| Biological Process | GO:0051480 | regulation of cytosolic calcium ion concentration |
| Biological Process | GO:2000535 | regulation of entry of bacterium into host cell |
| Biological Process | GO:0019217 | regulation of fatty acid metabolic process |
| Biological Process | GO:0086091 | regulation of heart rate by cardiac conduction |
| Biological Process | GO:0098903 | regulation of membrane repolarization during action potential |
| Biological Process | GO:1900027 | regulation of ruffle assembly |
| Biological Process | GO:0006940 | regulation of smooth muscle contraction |
| Biological Process | GO:0098911 | regulation of ventricular cardiac muscle cell action potential |
| Biological Process | GO:0009617 | response to bacterium |
| Biological Process | GO:0051592 | response to calcium ion |
| Biological Process | GO:0043627 | response to estrogen |
| Biological Process | GO:0001666 | response to hypoxia |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.
[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.