Search Results
Overview
| Uniprot ID | Q03154 |
|---|---|
| Protein Name | Aminoacylase-1 |
| Gene Name | ACY1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 129 | LEAVRRLKVEGHRFP |
| 218 | MEDTAAEKLHKVVNS |
| 221 | TAAEKLHKVVNSILA |
| 244 | LQSNPHLKEGSVTSV |
| 4 | ****MTSKGPEEEHP |
Function
Aminoacylase involved in the hydrolysis of N-acetylated and N-formylated amino acids. May act sequentially with APEH in the degradation of N-acylated peptides: APEH first cleaves N-acylaminoacids from N-acylated peptides, then ACY1 further hydrolyzes the N-acylaminoacid into free aminoacid and a carboxylate
Protein Sequence
10
MTSKGPEEEH
20
PSVTLFRQYL
30
RIRTVQPKPD
40
YGAAVAFFEE
50
TARQLGLGCQ
60
KVEVAPGYVV
70
TVLTWPGTNP
80
TLSSILLNSH
90
TDVVPVFKEH
100
WSHDPFEAFK
110
DSEGYIYARG
120
AQDMKCVSIQ
130
YLEAVRRLKV
140
EGHRFPRTIH
150
MTFVPDEEVG
160
GHQGMELFVQ
170
RPEFHALRAG
180
FALDEGIANP
190
TDAFTVFYSE
200
RSPWWVRVTS
210
TGRPGHASRF
220
MEDTAAEKLH
230
KVVNSILAFR
240
EKEWQRLQSN
250
PHLKEGSVTS
260
VNLTKLEGGV
270
AYNVIPATMS
280
ASFDFRVAPD
290
VDFKAFEEQL
300
QSWCQAAGEG
310
VTLEFAQKWM
320
HPQVTPTDDS
330
NPWWAAFSRV
340
CKDMNLTLEP
350
EIMPAATDNR
360
YIRAVGVPAL
370
GFSPMNRTPV
380
LLHDHDERLH
390
EAVFLRGVDI
400
YTRLLPALAS
VPALPSDS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Molecular Function | GO:0004046 | aminoacylase activity |
| Molecular Function | GO:0008463 | formylmethionine deformylase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0006520 | amino acid metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.