Search Results

Overview

Uniprot ID	Q03169
Protein Name	Tumor necrosis factor alpha-induced protein 2
Gene Name	TNFAIP2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
38	KEKKKKSKGLANVFC
49	NVFCVFTKGKKKKGQ
51	FCVFTKGKKKKGQPS
54	FTKGKKKKGQPSSAE

Function

May play a role as a mediator of inflammation and angiogenesis

Protein Sequence

10 MSEASSEDLV 20 PPLEAGAAPY 30 REEEEAAKKK 40 KEKKKKSKGL 50 ANVFCVFTKG 60 KKKKGQPSSA 70 EPEDAAGSRQ 80 GLDGPPPTVE 90 ELKAALERGQ 100 LEAARPLLAL 110 ERELAAAAAA 120 GGVSEEELVR 130 RQSKVEALYE 140 LLRDQVLGVL 150 RRPLEAPPER 160 LRQALAVVAE 170 QEREDRQAAA 180 AGPGTSGLAA 190 TRPRRWLQLW 200 RRGVAEAAEE 210 RMGQRPAAGA 220 EVPESVFLHL 230 GRTMKEDLEA 240 VVERLKPLFP 250 AEFGVVAAYA 260 ESYHQHFAAH 270 LAAVAQFELC 280 ERDTYMLLLW 290 VQNLYPNDII 300 NSPKLVGELQ 310 GMGLGSLLPP 320 RQIRLLEATF 330 LSSEAANVRE 340 LMDRALELEA 350 RRWAEDVPPQ 360 RLDGHCHSEL 370 AIDIIQITSQ 380 AQAKAESITL 390 DLGSQIKRVL 400 LVELPAFLRS 410 YQRAFNEFLE 420 RGKQLTNYRA 430 NVIANINNCL 440 SFRMSMEQNW 450 QVPQDTLSLL 460 LGPLGELKSH 470 GFDTLLQNLH 480 EDLKPLFKRF 490 THTRWAAPVE 500 TLENIIATVD 510 TRLPEFSELQ 520 GCFREELMEA 530 LHLHLVKEYI 540 IQLSKGRLVL 550 KTAEQQQQLA 560 GYILANADTI 570 QHFCTQHGSP 580 ATWLQPALPT 590 LAEIIRLQDP 600 SAIKIEVATY 610 ATCYPDFSKG 620 HLSAILAIKG 630 NLSNSEVKRI 640 RSILDVSMGA 650 QEPSRPLFSL IKVG

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000145	exocyst
Cellular Component	GO:0005615	extracellular space
Molecular Function	GO:0000149	SNARE binding
Biological Process	GO:0001525	angiogenesis
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0051601	exocyst localization
Biological Process	GO:0006887	exocytosis

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.