Search Results
Overview
| Uniprot ID | Q03188 |
|---|---|
| Protein Name | Centromere protein C |
| Gene Name | CENPC |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 563 | SSRKSTKKTNQSSKN |
| 727 | PKNRIHHKLVLPSNT |
| 84 | ECQKSHPKSVPVSSK |
Function
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions
Protein Sequence
10
MAASGLDHLK
20
NGYRRRFCRP
30
SRARDINTEQ
40
GQNVLEILQD
50
CFEEKSLAND
60
FSTNSTKSVP
70
NSTRKIKDTC
80
IQSPSKECQK
90
SHPKSVPVSS
100
KKKEASLQFV
110
VEPSEATNRS
120
VQAHEVHQKI
130
LATDVSSKNT
140
PDSKKISSRN
150
INDHHSEADE
160
EFYLSVGSPS
170
VLLDAKTSVS
180
QNVIPSSAQK
190
RETYTFENSV
200
NMLPSSTEVS
210
VKTKKRLNFD
220
DKVMLKKIEI
230
DNKVSDEEDK
240
TSEGQERKPS
250
GSSQNRIRDS
260
EYEIQRQAKK
270
SFSTLFLETV
280
KRKSESSPIV
290
RHAATAPPHS
300
CPPDDTKLIE
310
DEFIIDESDQ
320
SFASRSWITI
330
PRKAGSLKQR
340
TISPAESTAL
350
LQGRKSREKH
360
HNILPKTLAN
370
DKHSHKPHPV
380
ETSQPSDKTV
390
LDTSYALIGE
400
TVNNYRSTKY
410
EMYSKNAEKP
420
SRSKRTIKQK
430
QRRKFMAKPA
440
EEQLDVGQSK
450
DENIHTSHIT
460
QDEFQRNSDR
470
NMEEHEEMGN
480
DCVSKKQMPP
490
VGSKKSSTRK
500
DKEESKKKRF
510
SSESKNKLVP
520
EEVTSTVTKS
530
RRISRRPSDW
540
WVVKSEESPV
550
YSNSSVRNEL
560
PMHHNSSRKS
570
TKKTNQSSKN
580
IRKKTIPLKR
590
QKTATKGNQR
600
VQKFLNAEGS
610
GGIVGHDEIS
620
RCSLSEPLES
630
DEADLAKKKN
640
LDCSRSTRSS
650
KNEDNIMTAQ
660
NVPLKPQTSG
670
YTCNIPTESN
680
LDSGEHKTSV
690
LEESGPSRLN
700
NNYLMSGKND
710
VDDEEVHGSS
720
DDSKQSKVIP
730
KNRIHHKLVL
740
PSNTPNVRRT
750
KRTRLKPLEY
760
WRGERIDYQG
770
RPSGGFVISG
780
VLSPDTISSK
790
RKAKENIGKV
800
NKKSNKKRIC
810
LDNDERKTNL
820
MVNLGIPLGD
830
PLQPTRVKDP
840
ETREIILMDL
850
VRPQDTYQFF
860
VKHGELKVYK
870
TLDTPFFSTG
880
KLILGPQEEK
890
GKQHVGQDIL
900
VFYVNFGDLL
910
CTLHETPYIL
920
STGDSFYVPS
930
GNYYNIKNLR
940
NEESVLLFTQ
IKR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000779 | condensed chromosome, centromeric region |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005721 | pericentric heterochromatin |
| Molecular Function | GO:0019237 | centromeric DNA binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Biological Process | GO:0051315 | attachment of mitotic spindle microtubules to kinetochore |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0007059 | chromosome segregation |
| Biological Process | GO:0051382 | kinetochore assembly |
| Biological Process | GO:0000278 | mitotic cell cycle |
| Biological Process | GO:0051455 | spindle attachment to meiosis I kinetochore |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.