Search Results

Overview

Uniprot IDQ03252
Protein NameLamin-B2
Gene NameLMNB2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
133 AELDEVNKSAKKREG
150 TVAQGRVKDLESLFH
186 ELRAQLAKAEDGHAV
195 EDGHAVAKKQLEKET
223 QEELDFRKSVFEEEV
290 QAKLDSAKLSSDQND
298 LSSDQNDKAASAARE
81 LLLKISEKEEVTTRE

Function

Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404)

Protein Sequence

10 MSPPSPGRRR 20 EQRRPRAAAT 30 MATPLPGRAG 40 GPATPLSPTR 50 LSRLQEKEEL 60 RELNDRLAHY 70 IDRVRALELE 80 NDRLLLKISE 90 KEEVTTREVS 100 GIKALYESEL 110 ADARRVLDET 120 ARERARLQIE 130 IGKLRAELDE 140 VNKSAKKREG 150 ELTVAQGRVK 160 DLESLFHRSE 170 VELAAALSDK 180 RGLESDVAEL 190 RAQLAKAEDG 200 HAVAKKQLEK 210 ETLMRVDLEN 220 RCQSLQEELD 230 FRKSVFEEEV 240 RETRRRHERR 250 LVEVDSSRQQ 260 EYDFKMAQAL 270 EELRSQHDEQ 280 VRLYKLELEQ 290 TYQAKLDSAK 300 LSSDQNDKAA 310 SAAREELKEA 320 RMRLESLSYQ 330 LSGLQKQASA 340 AEDRIRELEE 350 AMAGERDKFR 360 KMLDAKEQEM 370 TEMRDVMQQQ 380 LAEYQELLDV 390 KLALDMEINA 400 YRKLLEGEEE 410 RLKLSPSPSS 420 RVTVSRATSS 430 SSGSLSATGR 440 LGRSKRKRLE 450 VEEPLGSGPS 460 VLGTGTGGSG 470 GFHLAQQASA 480 SGSVSIEEID 490 LEGKFVQLKN 500 NSDKDQSLGN 510 WRIKRQVLEG 520 EEIAYKFTPK 530 YILRAGQMVT 540 VWAAGAGVAH 550 SPPSTLVWKG 560 QSSWGTGESF 570 RTVLVNADGE 580 EVAMRTVKKS 590 SVMRENENGE 600 EEEEEAEFGE 610 EDLFHQQGDP 620 RTTSRGCYVM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005882 intermediate filament
Cellular Component GO:0005652 nuclear lamina
Cellular Component GO:0031965 nuclear membrane
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0005200 structural constituent of cytoskeleton
Biological Process GO:0031507 heterochromatin formation
Biological Process GO:0006998 nuclear envelope organization
Biological Process GO:0007097 nuclear migration
Biological Process GO:0051664 nuclear pore localization
Biological Process GO:0090435 protein localization to nuclear envelope

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.