Search Results
Overview
| Uniprot ID | Q03410 |
|---|---|
| Protein Name | Synaptonemal complex protein 1 |
| Gene Name | Sycp1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 678 | ELASTKQKFEEMINN |
Function
Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase (PubMed:1464329). Required for normal assembly of the central element of the synaptonemal complexes. Required for normal centromere pairing during meiosis. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility
Protein Sequence
10
MEKQKPFTLF
20
VPPRLSSSQV
30
SAVKPQTAGG
40
DSNYFKTVNK
50
CTEGDFGVPL
60
TMSSLSKNRE
70
NIDTDPAFQK
80
LSILPMLEQV
90
ANSGSCHYQE
100
GVNDSDFENS
110
EPMSRLYSKL
120
YKEAEKIKKW
130
KVSIESELKQ
140
KENKLQENRK
150
IIEAQRKAIQ
160
ELQFENEKVS
170
LKLEEEIQEN
180
KDLIKENNAT
190
RHWCNLLKET
200
CARSAEKTSK
210
YEYEREETRQ
220
VYVDLNNNIE
230
KMILAFEELR
240
VQAENARLEM
250
HFKLKEDHEK
260
IQHLEEEYQK
270
EVNNKENQVS
280
LLLIQSTEKE
290
NKMKDLTFLL
300
EESRDKANQL
310
EEKTKLQDEN
320
LKELNEKKDH
330
LTSELEDIKM
340
SMQRSMSTQK
350
TLEEDLQIAT
360
KTIYQLTEEK
370
EAQMEELNKA
380
KTTHSLVVTE
390
LKATTCTLEE
400
LLRTEQQRLE
410
NNEDQLKLIT
420
MELQKKSSEL
430
EEMTKFKNNK
440
EVELEELKTI
450
LAEDQKLLDE
460
KKQVEKLAEE
470
LQGKEQELTF
480
LLQTREKEIH
490
DLEVQVTVTK
500
TSEEHYLKQV
510
EEMKTELEKE
520
KLKNIELTAN
530
SDMLLLENKK
540
LVQEASDMVL
550
ELKKHQEDII
560
NCKKQEERML
570
KQIETLEEKE
580
MNLRDELESV
590
RKEFIQQGDE
600
VKCKLDKSEE
610
NARSIEYEVL
620
KKEKQMKILE
630
NKCNNLKKQI
640
ENKSKNIEEL
650
HQENKALKKK
660
SSAENKQLNA
670
YEIKVNKLEL
680
ELASTKQKFE
690
EMINNYQKEI
700
EIKKISEEKL
710
LGEVEKAKAT
720
VDEAVKLQKE
730
IDLRCQHKIA
740
EMVALMEKHK
750
HQYDKIVEER
760
DSELGLYKNR
770
EQEQSSAKVA
780
LETELSNIRN
790
ELVSLKKQLE
800
VEKEEKEKLK
810
MEQENTAILT
820
DKKDKKIQAS
830
LLESPEATSW
840
KFDSKTTPSQ
850
NISRLSSSMD
860
SGKSKDNRDS
870
LRASAKSILS
880
TTVTKEYTVK
890
TPTKKSIYQR
900
ENKYLPTGGS
910
NKKRKTVFEF
920
DVNSDSSETT
930
DLLSLVSEED
940
ISNRIYNNNT
950
PDSHLLVKTP
960
KQTPLSLSTP
970
ASFTKFGSLK
980
KMREDRWATI
990
AKIDRKRRLK
EAEKLFT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030849 | autosome |
| Cellular Component | GO:0000801 | central element |
| Cellular Component | GO:0005694 | chromosome |
| Cellular Component | GO:0000775 | chromosome, centromeric region |
| Cellular Component | GO:0000794 | condensed nuclear chromosome |
| Cellular Component | GO:0001673 | male germ cell nucleus |
| Cellular Component | GO:0000795 | synaptonemal complex |
| Cellular Component | GO:0000802 | transverse filament |
| Molecular Function | GO:0003690 | double-stranded DNA binding |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0051026 | chiasma assembly |
| Biological Process | GO:0007129 | homologous chromosome pairing at meiosis |
| Biological Process | GO:0051878 | lateral element assembly |
| Biological Process | GO:0000711 | meiotic DNA repair synthesis |
| Biological Process | GO:0051289 | protein homotetramerization |
| Biological Process | GO:0007131 | reciprocal meiotic recombination |
| Biological Process | GO:0032880 | regulation of protein localization |
| Biological Process | GO:0035092 | sperm DNA condensation |
| Biological Process | GO:0007283 | spermatogenesis |
| Biological Process | GO:0007130 | synaptonemal complex assembly |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.