Search Results
Overview
| Uniprot ID | Q03426 |
|---|---|
| Protein Name | Mevalonate kinase |
| Gene Name | MVK |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 220 | ALRYHQGKISSLKRS |
Function
Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis (PubMed:11278915, PubMed:18302342, PubMed:9325256, PubMed:9392419)
Protein Sequence
10
MLSEVLLVSA
20
PGKVILHGEH
30
AVVHGKVALA
40
VSLNLRTFLR
50
LQPHSNGKVD
60
LSLPNIGIKR
70
AWDVARLQSL
80
DTSFLEQGDV
90
TTPTSEQVEK
100
LKEVAGLPDD
110
CAVTERLAVL
120
AFLYLYLSIC
130
RKQRALPSLD
140
IVVWSELPPG
150
AGLGSSAAYS
160
VCLAAALLTV
170
CEEIPNPLKD
180
GDCVNRWTKE
190
DLELINKWAF
200
QGERMIHGNP
210
SGVDNAVSTW
220
GGALRYHQGK
230
ISSLKRSPAL
240
QILLTNTKVP
250
RNTRALVAGV
260
RNRLLKFPEI
270
VAPLLTSIDA
280
ISLECERVLG
290
EMGEAPAPEQ
300
YLVLEELIDM
310
NQHHLNALGV
320
GHASLDQLCQ
330
VTRARGLHSK
340
LTGAGGGGCG
350
ITLLKPGLEQ
360
PEVEATKQAL
370
TSCGFDCLET
380
SIGAPGVSIH
390
SATSLDSRVQ
QALDGL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0004496 | mevalonate kinase activity |
| Biological Process | GO:0006695 | cholesterol biosynthetic process |
| Biological Process | GO:0033489 | cholesterol biosynthetic process via desmosterol |
| Biological Process | GO:0033490 | cholesterol biosynthetic process via lathosterol |
| Biological Process | GO:0010142 | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| Biological Process | GO:0033386 | geranylgeranyl diphosphate biosynthetic process |
| Biological Process | GO:0019287 | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| Biological Process | GO:0008299 | isoprenoid biosynthetic process |
| Biological Process | GO:0050728 | negative regulation of inflammatory response |
| Biological Process | GO:0036197 | zymosterol biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.