Search Results
Overview
| Uniprot ID | Q03591 |
|---|---|
| Protein Name | Complement factor H-related protein 1 |
| Gene Name | CFHR1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 82 | EGWSPTPKCLRLCFF |
Function
Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism
Protein Sequence
10
MWLLVSVILI
20
SRISSVGGEA
30
TFCDFPKINH
40
GILYDEEKYK
50
PFSQVPTGEV
60
FYYSCEYNFV
70
SPSKSFWTRI
80
TCTEEGWSPT
90
PKCLRLCFFP
100
FVENGHSESS
110
GQTHLEGDTV
120
QIICNTGYRL
130
QNNENNISCV
140
ERGWSTPPKC
150
RSTDTSCVNP
160
PTVQNAHILS
170
RQMSKYPSGE
180
RVRYECRSPY
190
EMFGDEEVMC
200
LNGNWTEPPQ
210
CKDSTGKCGP
220
PPPIDNGDIT
230
SFPLSVYAPA
240
SSVEYQCQNL
250
YQLEGNKRIT
260
CRNGQWSEPP
270
KCLHPCVISR
280
EIMENYNIAL
290
RWTAKQKLYL
300
RTGESAEFVC
310
KRGYRLSSRS
320
HTLRTTCWDG
330
KLEYPTCAKR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0072562 | blood microparticle |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0001851 | complement component C3b binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Biological Process | GO:0006956 | complement activation |
| Biological Process | GO:0051838 | cytolysis by host of symbiont cells |
| Biological Process | GO:0032091 | negative regulation of protein binding |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.