Search Results

Overview

Uniprot IDQ03701
Protein NameCCAAT/enhancer-binding protein zeta
Gene NameCEBPZ
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
122 KKEVKIPKINNKNTA
126 KIPKINNKNTAESQR
13 EPLEFHAKRPWRPEE
142 SVNKVKNKNRPEPHS
228 KSKTNSQKGASSTWM
718 TSLWELKKLSVHFHP
787 PKRKHFIKDIRHLPV
949 STKKSKRKGTDDFDF

Function

Stimulates transcription from the HSP70 promoter

Protein Sequence

10 MAAVKEPLEF 20 HAKRPWRPEE 30 AVEDPDEEDE 40 DNTSEAENGF 50 SLEEVLRLGG 60 TKQDYLMLAT 70 LDENEEVIDG 80 GKKGAIDDLQ 90 QGELEAFIQN 100 LNLAKYTKAS 110 LVEEDEPAEK 120 ENSSKKEVKI 130 PKINNKNTAE 140 SQRTSVNKVK 150 NKNRPEPHSD 160 ENGSTTPKVK 170 KDKQNIFEFF 180 ERQTLLLRPG 190 GKWYDLEYSN 200 EYSLKPQPQD 210 VVSKYKTLAQ 220 KLYQHEINLF 230 KSKTNSQKGA 240 SSTWMKAIVS 250 SGTLGDRMAA 260 MILLIQDDAV 270 HTLQFVETLV 280 NLVKKKGSKQ 290 QCLMALDTFK 300 ELLITDLLPD 310 NRKLRIFSQR 320 PFDKLEQLSS 330 GNKDSRDRRL 340 ILWYFEHQLK 350 HLVAEFVQVL 360 ETLSHDTLVT 370 TKTRALTVAH 380 ELLCNKPEEE 390 KALLVQVVNK 400 LGDPQNRIAT 410 KASHLLETLL 420 CKHPNMKGVV 430 SGEVERLLFR 440 SNISSKAQYY 450 AICFLNQMAL 460 SHEESELANK 470 LITVYFCFFR 480 TCVKKKDVES 490 KMLSALLTGV 500 NRAYPYSQTG 510 DDKVREQIDT 520 LFKVLHIVNF 530 NTSVQALMLL 540 FQVMNSQQTI 550 SDRYYTALYR 560 KMLDPGLMTC 570 SKQAMFLNLV 580 YKSLKADIVL 590 RRVKAFVKRL 600 LQVTCQQMPP 610 FICGALYLVS 620 EILKAKPGLR 630 SQLDDHPESD 640 DEENFIDAND 650 DEDMEKFTDA 660 DKETEIVKKL 670 ETEETVPETD 680 VETKKPEVAS 690 WVHFDNLKGG 700 KQLNKYDPFS 710 RNPLFCGAEN 720 TSLWELKKLS 730 VHFHPSVALF 740 AKTILQGNYI 750 QYSGDPLQDF 760 TLMRFLDRFV 770 YRNPKPHKGK 780 ENTDSVVMQP 790 KRKHFIKDIR 800 HLPVNSKEFL 810 AKEESQIPVD 820 EVFFHRYYKK 830 VAVKEKQKRD 840 ADEESIEDVD 850 DEEFEELIDT 860 FEDDNCFSSG 870 KDDMDFAGNV 880 KKRTKGAKDN 890 TLDEDSEGSD 900 DELGNLDDDE 910 VSLGSMDDEE 920 FAEVDEDGGT 930 FMDVLDDESE 940 SVPELEVHSK 950 VSTKKSKRKG 960 TDDFDFAGSF 970 QGPRKKKRNL 980 NDSSLFVSAE 990 EFGHLLDENM 1000 GSKFDNIGMN 1010 AMANKDNASL 1020 KQLRWEAERD 1030 DWLHNRDAKS 1040 IIKKKKHFKK 1050 KRIKTTQKTK KQRK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016602 CCAAT-binding factor complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003713 transcription coactivator activity
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.