Search Results

Overview

Uniprot IDQ04446
Protein Name1,4-alpha-glucan-branching enzyme
Gene NameGBE1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
132 YIPPKQNKSVLVPHG
149 LKVVITSKSGEILYR
212 GISSHEGKVASYKHF
50 VDFQRRYKQFSQILK
578 DDDLLRYKFLNNFDR
647 TALPGKFKIVLDSDA
68 ENEGGIDKFSRGYES

Function

Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer (PubMed:26199317, PubMed:8463281, PubMed:8613547)

Protein Sequence

10 MAAPMTPAAR 20 PEDYEAALNA 30 ALADVPELAR 40 LLEIDPYLKP 50 YAVDFQRRYK 60 QFSQILKNIG 70 ENEGGIDKFS 80 RGYESFGVHR 90 CADGGLYCKE 100 WAPGAEGVFL 110 TGDFNGWNPF 120 SYPYKKLDYG 130 KWELYIPPKQ 140 NKSVLVPHGS 150 KLKVVITSKS 160 GEILYRISPW 170 AKYVVREGDN 180 VNYDWIHWDP 190 EHSYEFKHSR 200 PKKPRSLRIY 210 ESHVGISSHE 220 GKVASYKHFT 230 CNVLPRIKGL 240 GYNCIQLMAI 250 MEHAYYASFG 260 YQITSFFAAS 270 SRYGTPEELQ 280 ELVDTAHSMG 290 IIVLLDVVHS 300 HASKNSADGL 310 NMFDGTDSCY 320 FHSGPRGTHD 330 LWDSRLFAYS 340 SWEILRFLLS 350 NIRWWLEEYR 360 FDGFRFDGVT 370 SMLYHHHGVG 380 QGFSGDYSEY 390 FGLQVDEDAL 400 TYLMLANHLV 410 HTLCPDSITI 420 AEDVSGMPAL 430 CSPISQGGGG 440 FDYRLAMAIP 450 DKWIQLLKEF 460 KDEDWNMGDI 470 VYTLTNRRYL 480 EKCIAYAESH 490 DQALVGDKSL 500 AFWLMDAEMY 510 TNMSVLTPFT 520 PVIDRGIQLH 530 KMIRLITHGL 540 GGEGYLNFMG 550 NEFGHPEWLD 560 FPRKGNNESY 570 HYARRQFHLT 580 DDDLLRYKFL 590 NNFDRDMNRL 600 EERYGWLAAP 610 QAYVSEKHEG 620 NKIIAFERAG 630 LLFIFNFHPS 640 KSYTDYRVGT 650 ALPGKFKIVL 660 DSDAAEYGGH 670 QRLDHSTDFF 680 SEAFEHNGRP 690 YSLLVYIPSR 700 VALILQNVDL PN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Molecular Function GO:0003844 1,4-alpha-glucan branching enzyme activity
Molecular Function GO:0030246 carbohydrate binding
Molecular Function GO:0043169 cation binding
Molecular Function GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
Biological Process GO:0006091 generation of precursor metabolites and energy
Biological Process GO:0005978 glycogen biosynthetic process
Biological Process GO:0005977 glycogen metabolic process
Biological Process GO:0043524 negative regulation of neuron apoptotic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.