Search Results

Overview

Uniprot ID	Q04656
Protein Name	Copper-transporting ATPase 1
Gene Name	ATP7A
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
246	KKQPKYLKLGAIDVE

Function

ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:28389643, PubMed:31283225). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:11092760, PubMed:28389643). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity) (PubMed:28389643). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity)

Protein Sequence

10 MDPSMGVNSV 20 TISVEGMTCN 30 SCVWTIEQQI 40 GKVNGVHHIK 50 VSLEEKNATI 60 IYDPKLQTPK 70 TLQEAIDDMG 80 FDAVIHNPDP 90 LPVLTDTLFL 100 TVTASLTLPW 110 DHIQSTLLKT 120 KGVTDIKIYP 130 QKRTVAVTII 140 PSIVNANQIK 150 ELVPELSLDT 160 GTLEKKSGAC 170 EDHSMAQAGE 180 VVLKMKVEGM 190 TCHSCTSTIE 200 GKIGKLQGVQ 210 RIKVSLDNQE 220 ATIVYQPHLI 230 SVEEMKKQIE 240 AMGFPAFVKK 250 QPKYLKLGAI 260 DVERLKNTPV 270 KSSEGSQQRS 280 PSYTNDSTAT 290 FIIDGMHCKS 300 CVSNIESTLS 310 ALQYVSSIVV 320 SLENRSAIVK 330 YNASSVTPES 340 LRKAIEAVSP 350 GLYRVSITSE 360 VESTSNSPSS 370 SSLQKIPLNV 380 VSQPLTQETV 390 INIDGMTCNS 400 CVQSIEGVIS 410 KKPGVKSIRV 420 SLANSNGTVE 430 YDPLLTSPET 440 LRGAIEDMGF 450 DATLSDTNEP 460 LVVIAQPSSE 470 MPLLTSTNEF 480 YTKGMTPVQD 490 KEEGKNSSKC 500 YIQVTGMTCA 510 SCVANIERNL 520 RREEGIYSIL 530 VALMAGKAEV 540 RYNPAVIQPP 550 MIAEFIRELG 560 FGATVIENAD 570 EGDGVLELVV 580 RGMTCASCVH 590 KIESSLTKHR 600 GILYCSVALA 610 TNKAHIKYDP 620 EIIGPRDIIH 630 TIESLGFEAS 640 LVKKDRSASH 650 LDHKREIRQW 660 RRSFLVSLFF 670 CIPVMGLMIY 680 MMVMDHHFAT 690 LHHNQNMSKE 700 EMINLHSSMF 710 LERQILPGLS 720 VMNLLSFLLC 730 VPVQFFGGWY 740 FYIQAYKALK 750 HKTANMDVLI 760 VLATTIAFAY 770 SLIILLVAMY 780 ERAKVNPITF 790 FDTPPMLFVF 800 IALGRWLEHI 810 AKGKTSEALA 820 KLISLQATEA 830 TIVTLDSDNI 840 LLSEEQVDVE 850 LVQRGDIIKV 860 VPGGKFPVDG 870 RVIEGHSMVD 880 ESLITGEAMP 890 VAKKPGSTVI 900 AGSINQNGSL 910 LICATHVGAD 920 TTLSQIVKLV 930 EEAQTSKAPI 940 QQFADKLSGY 950 FVPFIVFVSI 960 ATLLVWIVIG 970 FLNFEIVETY 980 FPGYNRSISR 990 TETIIRFAFQ 1000 ASITVLCIAC 1010 PCSLGLATPT 1020 AVMVGTGVGA 1030 QNGILIKGGE 1040 PLEMAHKVKV 1050 VVFDKTGTIT 1060 HGTPVVNQVK 1070 VLTESNRISH 1080 HKILAIVGTA 1090 ESNSEHPLGT 1100 AITKYCKQEL 1110 DTETLGTCID 1120 FQVVPGCGIS 1130 CKVTNIEGLL 1140 HKNNWNIEDN 1150 NIKNASLVQI 1160 DASNEQSSTS 1170 SSMIIDAQIS 1180 NALNAQQYKV 1190 LIGNREWMIR 1200 NGLVINNDVN 1210 DFMTEHERKG 1220 RTAVLVAVDD 1230 ELCGLIAIAD 1240 TVKPEAELAI 1250 HILKSMGLEV 1260 VLMTGDNSKT 1270 ARSIASQVGI 1280 TKVFAEVLPS 1290 HKVAKVKQLQ 1300 EEGKRVAMVG 1310 DGINDSPALA 1320 MANVGIAIGT 1330 GTDVAIEAAD 1340 VVLIRNDLLD 1350 VVASIDLSRK 1360 TVKRIRINFV 1370 FALIYNLVGI 1380 PIAAGVFMPI 1390 GLVLQPWMGS 1400 AAMAASSVSV 1410 VLSSLFLKLY 1420 RKPTYESYEL 1430 PARSQIGQKS 1440 PSEISVHVGI 1450 DDTSRNSPKL 1460 GLLDRIVNYS 1470 RASINSLLSD 1480 KRSLNSVVTS 1490 EPDKHSLLVG 1500 DFREDDDTAL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030424	axon
Cellular Component	GO:0016323	basolateral plasma membrane
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0030425	dendrite
Cellular Component	GO:0031901	early endosome membrane
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0005770	late endosome
Cellular Component	GO:0033162	melanosome membrane
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0043005	neuron projection
Cellular Component	GO:0043025	neuronal cell body
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0030670	phagocytic vesicle membrane
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0014069	postsynaptic density
Cellular Component	GO:0005802	trans-Golgi network
Cellular Component	GO:0032588	trans-Golgi network membrane
Cellular Component	GO:0030140	trans-Golgi network transport vesicle
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0005507	copper ion binding
Molecular Function	GO:0005375	copper ion transmembrane transporter activity
Molecular Function	GO:0032767	copper-dependent protein binding
Molecular Function	GO:1903136	cuprous ion binding
Molecular Function	GO:0043682	P-type divalent copper transporter activity
Molecular Function	GO:0140581	P-type monovalent copper transporter activity
Molecular Function	GO:0016532	superoxide dismutase copper chaperone activity
Biological Process	GO:0001568	blood vessel development
Biological Process	GO:0001974	blood vessel remodeling
Biological Process	GO:0051216	cartilage development
Biological Process	GO:0006584	catecholamine metabolic process
Biological Process	GO:0021954	central nervous system neuron development
Biological Process	GO:0021702	cerebellar Purkinje cell differentiation
Biological Process	GO:0030199	collagen fibril organization
Biological Process	GO:0060003	copper ion export
Biological Process	GO:0015677	copper ion import
Biological Process	GO:0006825	copper ion transport
Biological Process	GO:0010273	detoxification of copper ion
Biological Process	GO:0042417	dopamine metabolic process
Biological Process	GO:0048251	elastic fiber assembly
Biological Process	GO:0042414	epinephrine metabolic process
Biological Process	GO:0030198	extracellular matrix organization
Biological Process	GO:0009101	glycoprotein biosynthetic process
Biological Process	GO:0031069	hair follicle morphogenesis
Biological Process	GO:0006878	intracellular copper ion homeostasis
Biological Process	GO:0006568	L-tryptophan metabolic process
Biological Process	GO:0007626	locomotory behavior
Biological Process	GO:0048286	lung alveolus development
Biological Process	GO:0007005	mitochondrion organization
Biological Process	GO:0048812	neuron projection morphogenesis
Biological Process	GO:0042415	norepinephrine metabolic process
Biological Process	GO:0043473	pigmentation
Biological Process	GO:0048023	positive regulation of melanin biosynthetic process
Biological Process	GO:0021860	pyramidal neuron development
Biological Process	GO:0002082	regulation of oxidative phosphorylation
Biological Process	GO:0019430	removal of superoxide radicals
Biological Process	GO:0042428	serotonin metabolic process
Biological Process	GO:0043588	skin development
Biological Process	GO:0042093	T-helper cell differentiation

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.