Search Results

Overview

Uniprot IDQ04724
Protein NameTransducin-like enhancer protein 1
Gene NameTLE1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
275 PRENGIDKNRLLKKD
281 DKNRLLKKDASSSPA
300 SASSTSLKSKEMSLH
309 KEMSLHEKASTPVLK
316 KASTPVLKSSTPTPR

Function

Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (By similarity). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG

Protein Sequence

10 MFPQSRHPTP 20 HQAAGQPFKF 30 TIPESLDRIK 40 EEFQFLQAQY 50 HSLKLECEKL 60 ASEKTEMQRH 70 YVMYYEMSYG 80 LNIEMHKQTE 90 IAKRLNTICA 100 QVIPFLSQEH 110 QQQVAQAVER 120 AKQVTMAELN 130 AIIGQQQLQA 140 QHLSHGHGPP 150 VPLTPHPSGL 160 QPPGIPPLGG 170 SAGLLALSSA 180 LSGQSHLAIK 190 DDKKHHDAEH 200 HRDREPGTSN 210 SLLVPDSLRG 220 TDKRRNGPEF 230 SNDIKKRKVD 240 DKDSSHYDSD 250 GDKSDDNLVV 260 DVSNEDPSSP 270 RASPAHSPRE 280 NGIDKNRLLK 290 KDASSSPAST 300 ASSASSTSLK 310 SKEMSLHEKA 320 STPVLKSSTP 330 TPRSDMPTPG 340 TSATPGLRPG 350 LGKPPAIDPL 360 VNQAAAGLRT 370 PLAVPGPYPA 380 PFGMVPHAGM 390 NGELTSPGAA 400 YASLHNMSPQ 410 MSAAAAAAAV 420 VAYGRSPMVG 430 FDPPPHMRVP 440 TIPPNLAGIP 450 GGKPAYSFHV 460 TADGQMQPVP 470 FPPDALIGPG 480 IPRHARQINT 490 LNHGEVVCAV 500 TISNPTRHVY 510 TGGKGCVKVW 520 DISHPGNKSP 530 VSQLDCLNRD 540 NYIRSCKLLP 550 DGCTLIVGGE 560 ASTLSIWDLA 570 APTPRIKAEL 580 TSSAPACYAL 590 AISPDSKVCF 600 SCCSDGNIAV 610 WDLHNQTLVR 620 QFQGHTDGAS 630 CIDISNDGTK 640 LWTGGLDNTV 650 RSWDLREGRQ 660 LQQHDFTSQI 670 FSLGYCPTGE 680 WLAVGMESSN 690 VEVLHVNKPD 700 KYQLHLHESC 710 VLSLKFAYCG 720 KWFVSTGKDN 730 LLNAWRTPYG 740 ASIFQSKESS 750 SVLSCDISVD 760 DKYIVTGSGD 770 KKATVYEVIY

Gene Ontology

Classification GO ID Description
Cellular Component GO:1990907 beta-catenin-TCF complex
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005667 transcription regulator complex
Molecular Function GO:0140297 DNA-binding transcription factor binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0009887 animal organ morphogenesis
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:2000811 negative regulation of anoikis
Biological Process GO:0043124 negative regulation of canonical NF-kappaB signal transduction
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0030178 negative regulation of Wnt signaling pathway
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0007165 signal transduction
Biological Process GO:0016055 Wnt signaling pathway

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.