Search Results

Overview

Uniprot IDQ04726
Protein NameTransducin-like enhancer protein 3
Gene NameTLE3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
225 ADYSMEAKKRKAEEK
226 DYSMEAKKRKAEEKD
281 DKARSLKKDAPTSPA
302 STPSSKTKDLGHNDK
309 KDLGHNDKSSTPGLK
316 KSSTPGLKSNTPTPR

Function

Transcriptional coregulator that binds to a number of transcription factors. Acts as a regulator of adipogenesis both by acting as a corepressor of Wnt signaling and coactivator for PPARG (PubMed:28689657). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (PubMed:28689657). Promotes diffentiation of white adipocytes by acting as a coactivator for PPARG and preventing the association between PRDM16 and PPARG, thereby preventing browning of white adipocytes (By similarity)

Protein Sequence

10 MYPQGRHPAP 20 HQPGQPGFKF 30 TVAESCDRIK 40 DEFQFLQAQY 50 HSLKVEYDKL 60 ANEKTEMQRH 70 YVMYYEMSYG 80 LNIEMHKQTE 90 IAKRLNTILA 100 QIMPFLSQEH 110 QQQVAQAVER 120 AKQVTMTELN 130 AIIGQQQLQA 140 QHLSHATHGP 150 PVQLPPHPSG 160 LQPPGIPPVT 170 GSSSGLLALG 180 ALGSQAHLTV 190 KDEKNHHELD 200 HRERESSANN 210 SVSPSESLRA 220 SEKHRGSADY 230 SMEAKKRKAE 240 EKDSLSRYDS 250 DGDKSDDLVV 260 DVSNEDPATP 270 RVSPAHSPPE 280 NGLDKARSLK 290 KDAPTSPASV 300 ASSSSTPSSK 310 TKDLGHNDKS 320 STPGLKSNTP 330 TPRNDAPTPG 340 TSTTPGLRSM 350 PGKPPGMDPI 360 GIMASALRTP 370 ISITSSYAAP 380 FAMMSHHEMN 390 GSLTSPGAYA 400 GLHNIPPQMS 410 AAAAAAAAAY 420 GRSPMVSFGA 430 VGFDPHPPMR 440 ATGLPSSLAS 450 IPGGKPAYSF 460 HVSADGQMQP 470 VPFPHDALAG 480 PGIPRHARQI 490 NTLSHGEVVC 500 AVTISNPTRH 510 VYTGGKGCVK 520 IWDISQPGSK 530 SPISQLDCLN 540 RDNYIRSCKL 550 LPDGRTLIVG 560 GEASTLTIWD 570 LASPTPRIKA 580 ELTSSAPACY 590 ALAISPDAKV 600 CFSCCSDGNI 610 AVWDLHNQTL 620 VRQFQGHTDG 630 ASCIDISHDG 640 TKLWTGGLDN 650 TVRSWDLREG 660 RQLQQHDFTS 670 QIFSLGYCPT 680 GEWLAVGMES 690 SNVEVLHHTK 700 PDKYQLHLHE 710 SCVLSLKFAY 720 CGKWFVSTGK 730 DNLLNAWRTP 740 YGASIFQSKE 750 SSSVLSCDIS 760 ADDKYIVTGS 770 GDKKATVYEV IY

Gene Ontology

Classification GO ID Description
Cellular Component GO:1990907 beta-catenin-TCF complex
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005667 transcription regulator complex
Molecular Function GO:0003713 transcription coactivator activity
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0009887 animal organ morphogenesis
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045444 fat cell differentiation
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:0120163 negative regulation of cold-induced thermogenesis
Biological Process GO:0007165 signal transduction
Biological Process GO:0050872 white fat cell differentiation
Biological Process GO:0016055 Wnt signaling pathway

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.