Search Results

Overview

Uniprot IDQ04727
Protein NameTransducin-like enhancer protein 4
Gene NameTLE4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
231 DYSSESKKQKTEEKE
287 DKTRLLKKDAPISPA
306 SSSTPSSKSKELSLN
308 STPSSKSKELSLNEK
322 KSTTPVSKSNTPTPR
7 *MIRDLSKMYPQTRH

Function

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (By similarity)

Protein Sequence

10 MIRDLSKMYP 20 QTRHPAPHQP 30 AQPFKFTISE 40 SCDRIKEEFQ 50 FLQAQYHSLK 60 LECEKLASEK 70 TEMQRHYVMY 80 YEMSYGLNIE 90 MHKQAEIVKR 100 LNAICAQVIP 110 FLSQEHQQQV 120 VQAVERAKQV 130 TMAELNAIIG 140 QQLQAQHLSH 150 GHGLPVPLTP 160 HPSGLQPPAI 170 PPIGSSAGLL 180 ALSSALGGQS 190 HLPIKDEKKH 200 HDNDHQRDRD 210 SIKSSSVSPS 220 ASFRGAEKHR 230 NSADYSSESK 240 KQKTEEKEIA 250 ARYDSDGEKS 260 DDNLVVDVSN 270 EDPSSPRGSP 280 AHSPRENGLD 290 KTRLLKKDAP 300 ISPASIASSS 310 STPSSKSKEL 320 SLNEKSTTPV 330 SKSNTPTPRT 340 DAPTPGSNST 350 PGLRPVPGKP 360 PGVDPLASSL 370 RTPMAVPCPY 380 PTPFGIVPHA 390 GMNGELTSPG 400 AAYAGLHNIS 410 PQMSAAAAAA 420 AAAAAYGRSP 430 VVGFDPHHHM 440 RVPAIPPNLT 450 GIPGGKPAYS 460 FHVSADGQMQ 470 PVPFPPDALI 480 GPGIPRHARQ 490 INTLNHGEVV 500 CAVTISNPTR 510 HVYTGGKGCV 520 KVWDISHPGN 530 KSPVSQLDCL 540 NRDNYIRSCR 550 LLPDGRTLIV 560 GGEASTLSIW 570 DLAAPTPRIK 580 AELTSSAPAC 590 YALAISPDSK 600 VCFSCCSDGN 610 IAVWDLHNQT 620 LVRQFQGHTD 630 GASCIDISND 640 GTKLWTGGLD 650 NTVRSWDLRE 660 GRQLQQHDFT 670 SQIFSLGYCP 680 TGEWLAVGME 690 NSNVEVLHVT 700 KPDKYQLHLH 710 ESCVLSLKFA 720 HCGKWFVSTG 730 KDNLLNAWRT 740 PYGASIFQSK 750 ESSSVLSCDI 760 SVDDKYIVTG 770 SGDKKATVYE VIY

Gene Ontology

Classification GO ID Description
Cellular Component GO:1990907 beta-catenin-TCF complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005667 transcription regulator complex
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0140297 DNA-binding transcription factor binding
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0016055 Wnt signaling pathway

Reference

PMID: N/A