Search Results

Overview

Uniprot ID	Q04760
Protein Name	Lactoylglutathione lyase
Gene Name	GLO1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
140	PDVYSACKRFEELGV
148	RFEELGVKFVKKPDD
151	ELGVKFVKKPDDGKM
44	LRVKDPKKSLDFYTR
83	EDKNDIPKEKDEKIA

Function

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (PubMed:20454679, PubMed:23122816, PubMed:9705294). Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (PubMed:19199007). Required for normal osteoclastogenesis (By similarity)

Protein Sequence

10 MAEPQPPSGG 20 LTDEAALSCC 30 SDADPSTKDF 40 LLQQTMLRVK 50 DPKKSLDFYT 60 RVLGMTLIQK 70 CDFPIMKFSL 80 YFLAYEDKND 90 IPKEKDEKIA 100 WALSRKATLE 110 LTHNWGTEDD 120 ETQSYHNGNS 130 DPRGFGHIGI 140 AVPDVYSACK 150 RFEELGVKFV 160 KKPDDGKMKG 170 LAFIQDPDGY 180 WIEILNPNKM ATLM

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0004462	lactoylglutathione lyase activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0005975	carbohydrate metabolic process
Biological Process	GO:0006749	glutathione metabolic process
Biological Process	GO:0009438	methylglyoxal metabolic process
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:0030316	osteoclast differentiation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.