Search Results
Overview
| Uniprot ID | Q04917 |
|---|---|
| Protein Name | 14-3-3 protein eta |
| Gene Name | YWHAH |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 142 | AEVASGEKKNSVVEA |
| 143 | EVASGEKKNSVVEAS |
| 50 | NLLSVAYKNVVGARR |
| 77 | TMADGNEKKLEKVKA |
Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0150048 | cerebellar granule cell to Purkinje cell synapse |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0014704 | intercalated disc |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098793 | presynapse |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0005159 | insulin-like growth factor receptor binding |
| Molecular Function | GO:0035259 | nuclear glucocorticoid receptor binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0017080 | sodium channel regulator activity |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Biological Process | GO:0006713 | glucocorticoid catabolic process |
| Biological Process | GO:0008104 | intracellular protein localization |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0086010 | membrane depolarization during action potential |
| Biological Process | GO:0050774 | negative regulation of dendrite morphogenesis |
| Biological Process | GO:0042921 | nuclear receptor-mediated glucocorticoid signaling pathway |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0099171 | presynaptic modulation of chemical synaptic transmission |
| Biological Process | GO:0045664 | regulation of neuron differentiation |
| Biological Process | GO:0002028 | regulation of sodium ion transport |
| Biological Process | GO:0048167 | regulation of synaptic plasticity |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0021762 | substantia nigra development |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.