Search Results
Overview
| Uniprot ID | Q04940 |
|---|---|
| Protein Name | Neurogranin |
| Gene Name | Nrgn |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 47 | HMARKKIKSGECGRK |
| 54 | KSGECGRKGPGPGGP |
Function
Regulates the affinity of calmodulin for calcium. Involved in synaptic plasticity and spatial learning (By similarity)
Protein Sequence
10
MDCCTESACS
20
KPDDDILDIP
30
LDDPGANAAA
40
AKIQASFRGH
50
MARKKIKSGE
60
CGRKGPGPGG
70
PGGAGGARGG
AGGGPSGD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0044327 | dendritic spine head |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0045211 | postsynaptic membrane |
| Cellular Component | GO:0012510 | trans-Golgi network transport vesicle membrane |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0070300 | phosphatidic acid binding |
| Molecular Function | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding |
| Biological Process | GO:0008306 | associative learning |
| Biological Process | GO:1900273 | positive regulation of long-term synaptic potentiation |
| Biological Process | GO:0099170 | postsynaptic modulation of chemical synaptic transmission |
| Biological Process | GO:0021537 | telencephalon development |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.