Search Results
Overview
| Uniprot ID | Q04970 |
|---|---|
| Protein Name | GTPase NRas |
| Gene Name | Nras |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 128 | PTRTVDTKQAHELAK |
Function
Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (By similarity). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Recognized by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity)
Protein Sequence
10
MTEYKLVVVG
20
AGGVGKSALT
30
IQLIQNHFVD
40
EYDPTIEDSY
50
RKQVVIDGET
60
CLLDILDTAG
70
QEEYSAMRDQ
80
YMRTGEGFLC
90
VFAINNSKSF
100
ADINLYREQI
110
KRVKDSDDVP
120
MVLVGNKCDL
130
PTRTVDTKQA
140
HELAKSYGIP
150
FIETSAKTRQ
160
GVEDAFYTLV
170
REIRQYRMKK
180
LNSSEDGTQG
CMGLPCVVM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0003925 | G protein activity |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Biological Process | GO:0042832 | defense response to protozoan |
| Biological Process | GO:0045445 | myoblast differentiation |
| Biological Process | GO:0048642 | negative regulation of skeletal muscle tissue development |
| Biological Process | GO:0045766 | positive regulation of angiogenesis |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0001938 | positive regulation of endothelial cell proliferation |
| Biological Process | GO:0048146 | positive regulation of fibroblast proliferation |
| Biological Process | GO:0032729 | positive regulation of type II interferon production |
| Biological Process | GO:0007265 | Ras protein signal transduction |
| Biological Process | GO:0010468 | regulation of gene expression |
| Biological Process | GO:0001932 | regulation of protein phosphorylation |
| Biological Process | GO:0050852 | T cell receptor signaling pathway |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.