Search Results
Overview
| Uniprot ID | Q05140 |
|---|---|
| Protein Name | Clathrin coat assembly protein AP180 |
| Gene Name | Snap91 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 150 | FDFARVKKGADGVMR |
| 163 | MRTMVPEKLLKSMPI |
| 28 | AVARAVCKATTHEVM |
| 38 | THEVMGPKKKHLDYL |
| 789 | ISGTTSKKGDLQWNA |
| 800 | QWNAGEKKLTGGANW |
| 903 | SPKKPPAKDPLADLN |
Function
Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats
Protein Sequence
10
MSGQTLTDRI
20
AAAQYSVTGS
30
AVARAVCKAT
40
THEVMGPKKK
50
HLDYLIQATN
60
ETNVNIPQMA
70
DTLFERATNS
80
SWVVVFKALV
90
TTHHLMVHGN
100
ERFIQYLASR
110
NTLFNLSNFL
120
DKSGSHGYDM
130
STFIRRYSRY
140
LNEKAFSYRQ
150
MAFDFARVKK
160
GADGVMRTMV
170
PEKLLKSMPI
180
LQGQIDALLE
190
FDVHPNELTN
200
GVINAAFMLL
210
FKDLIKLFAC
220
YNDGVINLLE
230
KFFEMKKGQC
240
KDALEIYKRF
250
LTRMTRVSEF
260
LKVADEVGID
270
KGDIPDLTQA
280
PSSLMETLEQ
290
HLNTLEGKKP
300
GNNEGSGAPS
310
PLSKSSPATT
320
VTSPNSTPAK
330
TIDTSPPVDI
340
FATASAAAPV
350
SSAKPSSDLL
360
DLQPDFSGAR
370
AGAAAPVPPP
380
TGGATAWGDL
390
LGEDSLAALS
400
SVPSEAPISD
410
PFAPEPSPPT
420
TTTEPASASA
430
SATTAVTAAT
440
TEVDLFGDAF
450
AASPGEAPAA
460
SEGATAPATP
470
APVAAALDAC
480
SGNDPFAPSE
490
GSAEAAPELD
500
LFAMKPPETS
510
APVVTPTAST
520
APPVPATAPS
530
PAPTAVAATA
540
ATTTAAAAAT
550
TTATTSAAAA
560
TTAAAPPALD
570
IFGDLFDSAP
580
EVAAASKPDV
590
APSIDLFGTD
600
AFSSPPRGAS
610
PVPESSLTAD
620
LLSGSGFHCA
630
EDDRHVPLFF
640
TAVDAFAAPS
650
PASTASPAKA
660
ESSGVIDLFG
670
DAFGSSASET
680
QPAPQAVSSS
690
SASADLLAGF
700
GGSFMAPSTT
710
PVTPAQNNLL
720
QPNFEAAFGT
730
TPSTSSSSSF
740
DPSGDLLMPT
750
MAPSGQPAPV
760
SMVPPSPAMS
770
ASKGLGSDLD
780
SSLASLVGNL
790
GISGTTSKKG
800
DLQWNAGEKK
810
LTGGANWQPK
820
VTPATWSAGV
830
PPQGTVPPTS
840
SVPPGAGAPS
850
VGQPGAGYGM
860
PPAGTGMTMM
870
PQQPVMFAQP
880
MMRPPFGAAA
890
VPGTQLSPSP
900
TPATQSPKKP
910
PAKDPLADLN
IKDFL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0043679 | axon terminus |
| Cellular Component | GO:0005905 | clathrin-coated pit |
| Cellular Component | GO:0030136 | clathrin-coated vesicle |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0098894 | extrinsic component of presynaptic endocytic zone membrane |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0098688 | parallel fiber to Purkinje cell synapse |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0045211 | postsynaptic membrane |
| Cellular Component | GO:0048787 | presynaptic active zone membrane |
| Cellular Component | GO:0042734 | presynaptic membrane |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Cellular Component | GO:0043195 | terminal bouton |
| Molecular Function | GO:0005545 | 1-phosphatidylinositol binding |
| Molecular Function | GO:0035615 | clathrin adaptor activity |
| Molecular Function | GO:0030276 | clathrin binding |
| Molecular Function | GO:0032050 | clathrin heavy chain binding |
| Molecular Function | GO:0000822 | inositol hexakisphosphate binding |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| Molecular Function | GO:0043274 | phospholipase binding |
| Molecular Function | GO:0160186 | phospholipase C inhibitor activity |
| Molecular Function | GO:0060961 | phospholipase D inhibitor activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0042169 | SH2 domain binding |
| Molecular Function | GO:0000149 | SNARE binding |
| Biological Process | GO:0007409 | axonogenesis |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0048268 | clathrin coat assembly |
| Biological Process | GO:0072583 | clathrin-dependent endocytosis |
| Biological Process | GO:0007163 | establishment or maintenance of cell polarity |
| Biological Process | GO:0048666 | neuron development |
| Biological Process | GO:0007269 | neurotransmitter secretion |
| Biological Process | GO:0050772 | positive regulation of axonogenesis |
| Biological Process | GO:1905445 | positive regulation of clathrin coat assembly |
| Biological Process | GO:2000809 | positive regulation of synaptic vesicle clustering |
| Biological Process | GO:1900244 | positive regulation of synaptic vesicle endocytosis |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:2000369 | regulation of clathrin-dependent endocytosis |
| Biological Process | GO:0030100 | regulation of endocytosis |
| Biological Process | GO:0051223 | regulation of protein transport |
| Biological Process | GO:1900242 | regulation of synaptic vesicle endocytosis |
| Biological Process | GO:2000331 | regulation of terminal button organization |
| Biological Process | GO:0048488 | synaptic vesicle endocytosis |
| Biological Process | GO:0006900 | vesicle budding from membrane |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.