Search Results
Overview
| Uniprot ID | Q05209 |
|---|---|
| Protein Name | Tyrosine-protein phosphatase non-receptor type 12 |
| Gene Name | PTPN12 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 712 | QERSEQKKSEGLITS |
Function
Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172)
Protein Sequence
10
MEQVEILRKF
20
IQRVQAMKSP
30
DHNGEDNFAR
40
DFMRLRRLST
50
KYRTEKIYPT
60
ATGEKEENVK
70
KNRYKDILPF
80
DHSRVKLTLK
90
TPSQDSDYIN
100
ANFIKGVYGP
110
KAYVATQGPL
120
ANTVIDFWRM
130
IWEYNVVIIV
140
MACREFEMGR
150
KKCERYWPLY
160
GEDPITFAPF
170
KISCEDEQAR
180
TDYFIRTLLL
190
EFQNESRRLY
200
QFHYVNWPDH
210
DVPSSFDSIL
220
DMISLMRKYQ
230
EHEDVPICIH
240
CSAGCGRTGA
250
ICAIDYTWNL
260
LKAGKIPEEF
270
NVFNLIQEMR
280
TQRHSAVQTK
290
EQYELVHRAI
300
AQLFEKQLQL
310
YEIHGAQKIA
320
DGVNEINTEN
330
MVSSIEPEKQ
340
DSPPPKPPRT
350
RSCLVEGDAK
360
EEILQPPEPH
370
PVPPILTPSP
380
PSAFPTVTTV
390
WQDNDRYHPK
400
PVLHMVSSEQ
410
HSADLNRNYS
420
KSTELPGKNE
430
STIEQIDKKL
440
ERNLSFEIKK
450
VPLQEGPKSF
460
DGNTLLNRGH
470
AIKIKSASPC
480
IADKISKPQE
490
LSSDLNVGDT
500
SQNSCVDCSV
510
TQSNKVSVTP
520
PEESQNSDTP
530
PRPDRLPLDE
540
KGHVTWSFHG
550
PENAIPIPDL
560
SEGNSSDINY
570
QTRKTVSLTP
580
SPTTQVETPD
590
LVDHDNTSPL
600
FRTPLSFTNP
610
LHSDDSDSDE
620
RNSDGAVTQN
630
KTNISTASAT
640
VSAATSTESI
650
STRKVLPMSI
660
ARHNIAGTTH
670
SGAEKDVDVS
680
EDSPPPLPER
690
TPESFVLASE
700
HNTPVRSEWS
710
ELQSQERSEQ
720
KKSEGLITSE
730
NEKCDHPAGG
740
IHYEMCIECP
750
PTFSDKREQI
760
SENPTEATDI
770
GFGNRCGKPK
780
GPRDPPSEWT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0002102 | podosome |
| Molecular Function | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity |
| Molecular Function | GO:0004721 | phosphoprotein phosphatase activity |
| Molecular Function | GO:0004725 | protein tyrosine phosphatase activity |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Biological Process | GO:0071364 | cellular response to epidermal growth factor stimulus |
| Biological Process | GO:1901185 | negative regulation of ERBB signaling pathway |
| Biological Process | GO:2000587 | negative regulation of platelet-derived growth factor receptor-beta signaling pathway |
| Biological Process | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| Biological Process | GO:0006470 | protein dephosphorylation |
| Biological Process | GO:0042058 | regulation of epidermal growth factor receptor signaling pathway |
| Biological Process | GO:0042246 | tissue regeneration |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.