Search Results
Overview
| Uniprot ID | Q05516 |
|---|---|
| Protein Name | Zinc finger and BTB domain-containing protein 16 |
| Gene Name | ZBTB16 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 154 | DRKARYLKNIFISKH |
Function
Acts as a transcriptional repressor (PubMed:10688654, PubMed:24359566). Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters (PubMed:10688654). May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312)
Protein Sequence
10
MDLTKMGMIQ
20
LQNPSHPTGL
30
LCKANQMRLA
40
GTLCDVVIMV
50
DSQEFHAHRT
60
VLACTSKMFE
70
ILFHRNSQHY
80
TLDFLSPKTF
90
QQILEYAYTA
100
TLQAKAEDLD
110
DLLYAAEILE
120
IEYLEEQCLK
130
MLETIQASDD
140
NDTEATMADG
150
GAEEEEDRKA
160
RYLKNIFISK
170
HSSEESGYAS
180
VAGQSLPGPM
190
VDQSPSVSTS
200
FGLSAMSPTK
210
AAVDSLMTIG
220
QSLLQGTLQP
230
PAGPEEPTLA
240
GGGRHPGVAE
250
VKTEMMQVDE
260
VPSQDSPGAA
270
ESSISGGMGD
280
KVEERGKEGP
290
GTPTRSSVIT
300
SARELHYGRE
310
ESAEQVPPPA
320
EAGQAPTGRP
330
EHPAPPPEKH
340
LGIYSVLPNH
350
KADAVLSMPS
360
SVTSGLHVQP
370
ALAVSMDFST
380
YGGLLPQGFI
390
QRELFSKLGE
400
LAVGMKSESR
410
TIGEQCSVCG
420
VELPDNEAVE
430
QHRKLHSGMK
440
TYGCELCGKR
450
FLDSLRLRMH
460
LLAHSAGAKA
470
FVCDQCGAQF
480
SKEDALETHR
490
QTHTGTDMAV
500
FCLLCGKRFQ
510
AQSALQQHME
520
VHAGVRSYIC
530
SECNRTFPSH
540
TALKRHLRSH
550
TGDHPYECEF
560
CGSCFRDEST
570
LKSHKRIHTG
580
EKPYECNGCG
590
KKFSLKHQLE
600
THYRVHTGEK
610
PFECKLCHQR
620
SRDYSAMIKH
630
LRTHNGASPY
640
QCTICTEYCP
650
SLSSMQKHMK
660
GHKPEEIPPD
670
WRIEKTYLYL
CYV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0016605 | PML body |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0017053 | transcription repressor complex |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0003712 | transcription coregulator activity |
| Molecular Function | GO:0001222 | transcription corepressor binding |
| Molecular Function | GO:0031703 | type 2 angiotensin receptor binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0051216 | cartilage development |
| Biological Process | GO:0007417 | central nervous system development |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0042733 | embryonic digit morphogenesis |
| Biological Process | GO:0035116 | embryonic hindlimb morphogenesis |
| Biological Process | GO:0030097 | hemopoiesis |
| Biological Process | GO:0001823 | mesonephros development |
| Biological Process | GO:0030099 | myeloid cell differentiation |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0045638 | negative regulation of myeloid cell differentiation |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0043931 | ossification involved in bone maturation |
| Biological Process | GO:0061036 | positive regulation of cartilage development |
| Biological Process | GO:0032332 | positive regulation of chondrocyte differentiation |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0045600 | positive regulation of fat cell differentiation |
| Biological Process | GO:0051138 | positive regulation of NK T cell differentiation |
| Biological Process | GO:0045778 | positive regulation of ossification |
| Biological Process | GO:0034504 | protein localization to nucleus |
| Biological Process | GO:0016567 | protein ubiquitination |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0045066 | regulatory T cell differentiation |
| Biological Process | GO:0002394 | tolerance induction in gut-associated lymphoid tissue |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.