Search Results
Overview
| Uniprot ID | Q05683 |
|---|---|
| Protein Name | Glutamate decarboxylase 2 |
| Gene Name | Gad2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 172 | TTLKYAIKTGHPRYF |
| 309 | IKCDERGKMIPSDLE |
| 528 | ERMSRLSKVAPVIKA |
| 78 | VACTCDQKPCSCPKG |
Function
Catalyzes the production of GABA
Protein Sequence
10
MASPGSGFWS
20
FGSEDGSGDP
30
ENPGTARAWC
40
QVAQKFTGGI
50
GNKLCALLYG
60
DSEKPAESGG
70
SVTSRAATRK
80
VACTCDQKPC
90
SCPKGDVNYA
100
LLHATDLLPA
110
CEGERPTLAF
120
LQDVMNILLQ
130
YVVKSFDRST
140
KVIDFHYPNE
150
LLQEYNWELA
160
DQPQNLEEIL
170
THCQTTLKYA
180
IKTGHPRYFN
190
QLSTGLDMVG
200
LAADWLTSTA
210
NTNMFTYEIA
220
PVFVLLEYVT
230
LKKMREIIGW
240
PGGSGDGIFS
250
PGGAISNMYA
260
MLIARYKMFP
270
EVKEKGMAAV
280
PRLIAFTSEH
290
SHFSLKKGAA
300
ALGIGTDSVI
310
LIKCDERGKM
320
IPSDLERRIL
330
EVKQKGFVPF
340
LVSATAGTTV
350
YGAFDPLLAV
360
ADICKKYKIW
370
MHVDAAWGGG
380
LLMSRKHKWK
390
LNGVERANSV
400
TWNPHKMMGV
410
PLQCSALLVR
420
EEGLMQSCNQ
430
MHASYLFQQD
440
KHYDLSYDTG
450
DKALQCGRHV
460
DVFKLWLMWR
470
AKGTTGFEAH
480
IDKCLELAEY
490
LYNIIKNREG
500
YEMVFDGKPQ
510
HTNVCFWFVP
520
PSLRVLEDNE
530
ERMSRLSKVA
540
PVIKARMMEY
550
GTTMVSYQPL
560
GDKVNFFRMV
570
ISNPAATHQD
580
IDFLIEEIER
LGQDL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0098982 | GABA-ergic synapse |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0060077 | inhibitory synapse |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0042734 | presynaptic membrane |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Molecular Function | GO:0016595 | glutamate binding |
| Molecular Function | GO:0004351 | glutamate decarboxylase activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0030170 | pyridoxal phosphate binding |
| Biological Process | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus |
| Biological Process | GO:0071456 | cellular response to hypoxia |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0006540 | gamma-aminobutyrate shunt |
| Biological Process | GO:0009449 | gamma-aminobutyric acid biosynthetic process |
| Biological Process | GO:0061771 | response to caloric restriction |
| Biological Process | GO:0042220 | response to cocaine |
| Biological Process | GO:0071548 | response to dexamethasone |
| Biological Process | GO:0032570 | response to progesterone |
| Biological Process | GO:0006950 | response to stress |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.