Search Results

Overview

Uniprot IDQ05707
Protein NameCollagen alpha-1(XIV) chain
Gene NameCOL14A1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1093 KLNAYKTKETLLDAI
1101 ETLLDAIKHISYKGG
1152 RSQDDVNKISREMQL
1351 FEGPEIRKIFYGSFH
261 GSRTGVSKIGILITD

Function

Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity)

Protein Sequence

10 MKIFQRKMRY 20 WLLPPFLAIV 30 YFCTIVQGQV 40 APPTRLRYNV 50 ISHDSIQISW 60 KAPRGKFGGY 70 KLLVTPTSGG 80 KTNQLNLQNT 90 ATKAIIQGLM 100 PDQNYTVQII 110 AYNKDKESKP 120 AQGQFRIKDL 130 EKRKDPKPRV 140 KVVDRGNGSR 150 PSSPEEVKFV 160 CQTPAIADIV 170 ILVDGSWSIG 180 RFNFRLVRHF 190 LENLVTAFDV 200 GSEKTRIGLA 210 QYSGDPRIEW 220 HLNAFSTKDE 230 VIEAVRNLPY 240 KGGNTLTGLA 250 LNYIFENSFK 260 PEAGSRTGVS 270 KIGILITDGK 280 SQDDIIPPSR 290 NLRESGVELF 300 AIGVKNADVN 310 ELQEIASEPD 320 STHVYNVAEF 330 DLMHTVVESL 340 TRTLCSRVEE 350 QDREIKASAH 360 AITGPPTELI 370 TSEVTARSFM 380 VNWTHAPGNV 390 EKYRVVYYPT 400 RGGKPDEVVV 410 DGTVSSTVLK 420 NLMSLTEYQI 430 AVFAIYAHTA 440 SEGLRGTETT 450 LALPMASDLL 460 LYDVTENSMR 470 VKWDAVPGAS 480 GYLILYAPLT 490 EGLAGDEKEM 500 KIGETHTDIE 510 LSGLLPNTEY 520 TVTVYAMFGE 530 EASDPVTGQE 540 TTLALSPPRN 550 LRISNVGSNS 560 ARLTWDPTSR 570 QINGYRIVYN 580 NADGTEINEV 590 EVDPITTFPL 600 KGLTPLTEYT 610 IAIFSIYDEG 620 QSEPLTGVFT 630 TEEVPAQQYL 640 EIDEVTTDSF 650 RVTWHPLSAD 660 EGLHKLMWIP 670 VYGGKTEEVV 680 LKEEQDSHVI 690 EGLEPGTEYE 700 VSLLAVLDDG 710 SESEVVTAVG 720 TTLDSFWTEP 730 ATTIVPTTSV 740 TSVFQTGIRN 750 LVVGDETTSS 760 LRVKWDISDS 770 DVQQFRVTYM 780 TAQGDPEEEV 790 IGTVMVPGSQ 800 NNLLLKPLLP 810 DTEYKVTVTP 820 IYTDGEGVSV 830 SAPGKTLPSS 840 GPQNLRVSEE 850 WYNRLRITWD 860 PPSSPVKGYR 870 IVYKPVSVPG 880 PTLETFVGAD 890 INTILITNLL 900 SGMDYNVKIF 910 ASQASGFSDA 920 LTGMVKTLFL 930 GVTNLQAKHV 940 EMTSLCAHWQ 950 VHRHATAYRV 960 VIESLQDRQK 970 QESTVGGGTT 980 RHCFYGLQPD 990 SEYKISVYTK 1000 LQEIEGPSVS 1010 IMEKTQSLPT 1020 RPPTFPPTIP 1030 PAKEVCKAAK 1040 ADLVFMVDGS 1050 WSIGDENFNK 1060 IISFLYSTVG 1070 ALNKIGTDGT 1080 QVAMVQFTDD 1090 PRTEFKLNAY 1100 KTKETLLDAI 1110 KHISYKGGNT 1120 KTGKAIKYVR 1130 DTLFTAESGT 1140 RRGIPKVIVV 1150 ITDGRSQDDV 1160 NKISREMQLD 1170 GYSIFAIGVA 1180 DADYSELVSI 1190 GSKPSARHVF 1200 FVDDFDAFKK 1210 IEDELITFVC 1220 ETASATCPVV 1230 HKDGIDLAGF 1240 KMMEMFGLVE 1250 KDFSSVEGVS 1260 MEPGTFNVFP 1270 CYQLHKDALV 1280 SQPTRYLHPE 1290 GLPSDYTISF 1300 LFRILPDTPQ 1310 EPFALWEILN 1320 KNSDPLVGVI 1330 LDNGGKTLTY 1340 FNYDQSGDFQ 1350 TVTFEGPEIR 1360 KIFYGSFHKL 1370 HIVVSETLVK 1380 VVIDCKQVGE 1390 KAMNASANIT 1400 SDGVEVLGKM 1410 VRSRGPGGNS 1420 APFQLQMFDI 1430 VCSTSWANTD 1440 KCCELPGLRD 1450 DESCPDLPHS 1460 CSCSETNEVA 1470 LGPAGPPGGP 1480 GLRGPKGQQG 1490 EPGPKGPDGP 1500 RGEIGLPGPQ 1510 GPPGPQGPSG 1520 LSIQGMPGMP 1530 GEKGEKGDTG 1540 LPGPQGIPGG 1550 VGSPGRDGSP 1560 GQRGLPGKDG 1570 SSGPPGPPGP 1580 IGIPGTPGVP 1590 GITGSMGPQG 1600 ALGPPGVPGA 1610 KGERGERGDL 1620 QSQAMVRSVA 1630 RQVCEQLIQS 1640 HMARYTAILN 1650 QIPSHSSSIR 1660 TVQGPPGEPG 1670 RPGSPGAPGE 1680 QGPPGTPGFP 1690 GNAGVPGTPG 1700 ERGLTGIKGE 1710 KGNPGVGTQG 1720 PRGPPGPAGP 1730 SGESRPGSPG 1740 PPGSPGPRGP 1750 PGHLGVPGPQ 1760 GPSGQPGYCD 1770 PSSCSAYGVR 1780 APHPDQPEFT 1790 PVQDELEAME LWGPGV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005581 collagen trimer
Cellular Component GO:0005596 collagen type XIV trimer
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005614 interstitial matrix
Molecular Function GO:0005518 collagen binding
Molecular Function GO:0005201 extracellular matrix structural constituent
Molecular Function GO:0030020 extracellular matrix structural constituent conferring tensile strength
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Molecular Function GO:0003723 RNA binding
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0030199 collagen fibril organization
Biological Process GO:0030198 extracellular matrix organization

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.