Search Results
Overview
| Uniprot ID | Q05764 |
|---|---|
| Protein Name | Beta-adducin |
| Gene Name | Add2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 163 | YVTLRVSKEQDHFLI |
| 276 | ADRINLQKCLGPTCK |
| 464 | RPKTTWMKADEVEKS |
| 470 | MKADEVEKSSSGMPI |
| 682 | DGDSYKDKTESVTSG |
Function
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity)
Protein Sequence
10
MSEDTVPEAA
20
SPPPSQGQHY
30
FDRFSEDDPE
40
YLRLRNRAAD
50
LRQDFNLMEQ
60
KKRVTMILQS
70
PSFREELEGL
80
IQEQMKKGNN
90
SSNIWALRQI
100
ADFMASTSHA
110
VFPASSMNFS
120
MMTPINDLHT
130
ADSLNLAKGE
140
RLMRCKISSV
150
YRLLDLYGWA
160
QLSDTYVTLR
170
VSKEQDHFLI
180
SPKGVSCSEV
190
TASSLIKVNI
200
LGEVVEKGSS
210
CFPVDTTGFS
220
LHSAIYAARP
230
DVRCAIHLHT
240
PATAAVSAMK
250
CGLLPVSHNA
260
LLVGDMAYYD
270
FNGEMEQEAD
280
RINLQKCLGP
290
TCKILVLRNH
300
GMVALGDTVE
310
EAFYKVFHLQ
320
AACEVQVSAL
330
SSAGGTENLI
340
LLEQEKHRPH
350
EVGSVQWAGS
360
TFGPMQKSRL
370
GEHEFEALMR
380
MLDNLGYRTG
390
YTYRHPFVQE
400
KTKHKSEVEI
410
PATVTAFVFE
420
EDGVPVPALR
430
QHAQKQQKEK
440
TRWLNTPNTY
450
LRVNVADEVQ
460
RNMGSPRPKT
470
TWMKADEVEK
480
SSSGMPIRIE
490
NPNQFVPLYT
500
DPQEVLDMRN
510
KIREQNRQDI
520
KSAGPQSQLL
530
ASVIAEKSRS
540
PSTESQLASK
550
GDADTKDELE
560
ETVPNPFSQL
570
TDQELEEYKK
580
EVERKKLEQE
590
QEGEKDAATE
600
EPGSPVKSTP
610
ASPVQSPTRA
620
GTKSPAVSPS
630
KASEDAKKTE
640
VSEANTEPEP
650
EKPEGVVVNG
660
KEEEPCVEEV
670
LSKGPGQMTT
680
NADTDGDSYK
690
DKTESVTSGP
700
LSPEGSPSKS
710
PSKKKKKFRT
720
PSFLKKSKKK
EKVES
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0008290 | F-actin capping protein complex |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0044853 | plasma membrane raft |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0014069 | postsynaptic density |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0008093 | cytoskeletal anchor activity |
| Molecular Function | GO:0046983 | protein dimerization activity |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0030507 | spectrin binding |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0051017 | actin filament bundle assembly |
| Biological Process | GO:0051016 | barbed-end actin filament capping |
| Biological Process | GO:0030097 | hemopoiesis |
| Biological Process | GO:0050900 | leukocyte migration |
| Biological Process | GO:0050901 | leukocyte tethering or rolling |
| Biological Process | GO:0006811 | monoatomic ion transport |
| Biological Process | GO:0065003 | protein-containing complex assembly |
| Biological Process | GO:0007416 | synapse assembly |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.