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Overview

Uniprot IDQ05D32
Protein NameCTD small phosphatase-like protein 2
Gene NameCTDSPL2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
26 RTARAKRKYSEVDDS
53 TGLLSSIKKFIKGST
57 SSIKKFIKGSTPKEE
7 *MRLRTRKASQQSNQ
95 RAGEKPNKQISRVRR

Function

Serine/threonine phosphatase that promotes gluconeogenesis by dephosphorylating FOXO1 and FOXO3A, promoting their nuclear retention and enhancing their transcriptional activity on PCK1 and G6PC1, key enzymes in hepatic gluconeogenesis (PubMed:28851713). Essential for proper embryonic skeletal development by regulating chondrocyte survival through dephosphorylation of FOXO3 (By similarity). By maintaining FOXO3 in its active, dephosphorylated form, inhibits excessive apoptosis of chondrocytes, which is essential for normal endochondral ossification and cartilage formation (By similarity)

Protein Sequence

10 MRLRTRKASQ 20 QSNQIQTQRT 30 ARAKRKYSEV 40 DDSLPSGGEK 50 PSKNETGLLS 60 SIKKFIKGST 70 PKEERENPSK 80 RSRIERDIDN 90 NLITSTPRAG 100 EKPNKQISRV 110 RRKSQVNGEA 120 GSYEMTNQHV 130 KQNGKLEDNP 140 SSGSPPRTTL 150 LGTIFSPVFN 160 FFSPANKNGT 170 SGSDSPGQAV 180 EAEEIVKQLD 190 MEQVDEITTS 200 TTTSTNGAAY 210 SNQAVQVRPS 220 LNNGLEEAEE 230 TVNRDIPPLT 240 APVTPDSGYS 250 SAHAEATYEE 260 DWEVFDPYYF 270 IKHVPPLTEE 280 QLNRKPALPL 290 KTRSTPEFSL 300 VLDLDETLVH 310 CSLNELEDAA 320 LTFPVLFQDV 330 IYQVYVRLRP 340 FFREFLERMS 350 QMYEIILFTA 360 SKKVYADKLL 370 NILDPKKQLV 380 RHRLFREHCV 390 CVQGNYIKDL 400 NILGRDLSKT 410 IIIDNSPQAF 420 AYQLSNGIPI 430 ESWFMDKNDN 440 ELLKLIPFLE 450 KLVELNEDVR 460 PHIRDRFRLH DLLPPD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0004721 phosphoprotein phosphatase activity
Molecular Function GO:0004722 protein serine/threonine phosphatase activity
Molecular Function GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity
Biological Process GO:0060348 bone development
Biological Process GO:0051216 cartilage development
Biological Process GO:0048706 embryonic skeletal system development
Biological Process GO:0003430 growth plate cartilage chondrocyte growth
Biological Process GO:0045722 positive regulation of gluconeogenesis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.