Search Results
Overview
| Uniprot ID | Q06203 |
|---|---|
| Protein Name | Amidophosphoribosyltransferase |
| Gene Name | PPAT |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 372 | RQLGVAKKFGVLSDN |
Function
Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Protein Sequence
10
MELEELGIRE
20
ECGVFGCIAS
30
GEWPTQLDVP
40
HVITLGLVGL
50
QHRGQESAGI
60
VTSDGSSVPT
70
FKSHKGMGLV
80
NHVFTEDNLK
90
KLYVSNLGIG
100
HTRYATTGKC
110
ELENCQPFVV
120
ETLHGKIAVA
130
HNGELVNAAR
140
LRKKLLRHGI
150
GLSTSSDSEM
160
ITQLLAYTPP
170
QEQDDTPDWV
180
ARIKNLMKEA
190
PTAYSLLIMH
200
RDVIYAVRDP
210
YGNRPLCIGR
220
LIPVSDINDK
230
EKKTSETEGW
240
VVSSESCSFL
250
SIGARYYREV
260
LPGEIVEISR
270
HNVQTLDIIS
280
RSEGNPVAFC
290
IFEYVYFARP
300
DSMFEDQMVY
310
TVRYRCGQQL
320
AIEAPVDADL
330
VSTVPESATP
340
AALAYAGKCG
350
LPYVEVLCKN
360
RYVGRTFIQP
370
NMRLRQLGVA
380
KKFGVLSDNF
390
KGKRIVLVDD
400
SIVRGNTISP
410
IIKLLKESGA
420
KEVHIRVASP
430
PIKYPCFMGI
440
NIPTKEELIA
450
NKPEFDHLAE
460
YLGANSVVYL
470
SVEGLVSSVQ
480
EGIKFKKQKE
490
KKHDIMIQEN
500
GNGLECFEKS
510
GHCTACLTGK
YPVELEW
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0051539 | 4 iron, 4 sulfur cluster binding |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0004044 | amidophosphoribosyltransferase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0044208 | 'de novo' AMP biosynthetic process |
| Biological Process | GO:0006189 | 'de novo' IMP biosynthetic process |
| Biological Process | GO:0097294 | 'de novo' XMP biosynthetic process |
| Biological Process | GO:0006177 | GMP biosynthetic process |
| Biological Process | GO:0009113 | purine nucleobase biosynthetic process |
| Biological Process | GO:0006164 | purine nucleotide biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.